Efficient acetate sensor in biological media based on a selective Excited State Proton Transfer (ESPT) reaction

[Display omitted] •“On/off” fluorescent dye to detect acetate.•High sensitivity Acetate detection in biological serum is reported.•Acetate ions are relevant in physiological processes because it participates directly and/or indirectly in cancer metabolism. We have synthesized a new fluoride−containi...

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Published inSensors and actuators. B, Chemical Vol. 250; pp. 623 - 628
Main Authors Puente-Muñoz, Virginia, Paredes, Jose M., Resa, Sandra, Ortuño, Ana M., Talavera, Eva M., Miguel, Delia, Cuerva, Juan M., Crovetto, Luis
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier B.V 01.10.2017
Elsevier Science Ltd
Subjects
Acetate sensor
Chemical synthesis
Excited state proton transfer (ESPT) reaction
Fatty acids
Fluorescence
Fluorescent probe
Hydrogen bonds
Metabolites
Protons
Acetate sensor
Fluorescent probe
Excited state proton transfer (ESPT) reaction
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Summary:[Display omitted] •“On/off” fluorescent dye to detect acetate.•High sensitivity Acetate detection in biological serum is reported.•Acetate ions are relevant in physiological processes because it participates directly and/or indirectly in cancer metabolism. We have synthesized a new fluoride−containing xanthenic dye able to dynamically and quantitatively detect acetate anion, a biologically relevant analyte, in water. We studied deeply the photophysical properties of the compound and verified its use as an acetate probe in synthetic serum.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2017.04.191