Synthesis and anticancer property of three new Cu(II) coordination polymers constructed by the bifunctional substituted-polynitrogen heterocyclic ligands

• Published in: Inorganica Chimica Acta Vol. 522; p. 120380
• Main Authors: Zhang, Ao-Lin, Li, Xin-Chen, Min, Juan, Tan, Li-Tao, Xu, Hong-Liang, Zhu, Xiao-Ge, Yao, Yu-Xin, Zheng, Zu-Hui, Zhu, Jian-Wei, Yang, Jie
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2021; Elsevier Science Ltd
• Subjects: Anticancer; Anticancer properties; Chemical analysis; Coordination polymers; Copper chloride; Crystal structure; Cu(II); Cytotoxicity; Fluorescence; Hatzpa; Hphtz; Hpytzipa; Infrared analysis; Ligands; Propionic acid; Single crystals; Substitutes; Toxicity; Hatzpa; Cu(II); Anticancer; Hphtz; Hpytzipa
• ISSN: 0020-1693; 1873-3255
• DOI: 10.1016/j.ica.2021.120380

In the present study, three different substituted-polynitrogen heterocyclic ligands, Hatzpa (Hatzpa = 3-(5-Amino-tetrazol-1-yl)-propionic acid), Hpytzipa (Hpytzipa = 2-(5-Pyridin-3-yl-tetrazol-2-yl)-propionic acid), Hphtz (Hphtz = 4-(4-hydroxyphenyl)-1,2,4-triazole) have been chosen to react with CuCl2·2H2O, resulting in the formation of three new compounds [Cu(atzpa)2] (1), [Cu(pytzipa)2] (2) and [Cu4(Hphtz)8](ClO4)4·4H2O (3). Complex 1 displays a complex 2D structure; complex 2 shows a 2D layer network; complex 3 shows a tetranuclear Cu(II) structure. These compounds show considerable cytotoxicity towards human cervical cancer cells (HeLa). The MTT assay suggests that compound 2 with lowest half maximum inhibitory concentration (IC50) is the most cytotoxic, compared with compounds 1 and 3. In addition, the cytotoxicity was also confirmed by DAPI fluorescent staining method. The migration of HeLa cells is inhibited by NPs of the three compounds. The results show that complex 1–3 NPs can inhibit cell proliferation and migration in vitro. [Display omitted] •Three new Cu(II) coordination polymers have been prepared, namely [Cu(atzpa)2] (1), [Cu(pytzipa)2] (2) and [Cu4(Hphtz)8](ClO4)4·4H2O (3).•Complex 1 displays a complex 2D structure; complex 2 shows a 2D layer network; complex 3 shows a tetranuclear Cu(II) structure.•These compounds show considerable cytotoxicity towards human cervical cancer cells (HeLa).•The complexes 1–3 NPs can inhibit cell proliferation and migration in vitro. Three different substituted multi-nitrogen heterocyclic ligands, Hatzpa (Hatzpa = 3-(5-Amino-tetrazol-1-yl)-propionic acid), Hpytzipa (Hpytzipa = 2-(5-Pyridin-3-yl-tetrazol-2-yl)-propionic acid), Hphtz (Hphtz = 4-(4-hydroxyphenyl)-1,2,4-triazole) have been chosen to react with CuCl2·2H2O, resulting in the formation of three new complexes [Cu(atzpa)2] (1), [Cu(pytzipa)2] (2) and [Cu4(Hphtz)8](ClO4)4·4H2O (3). The coordination sites of the three ligands are mainly affected by the different substituents of the polynitrogen heterocycle. These complexes have been characterized by elemental analysis, IR and single crystal X-ray diffraction. Complex 1 displays a 2D structure; complex 2 shows a 2D layer network; complex 3 shows a tetranuclear Cu(II) structure. These complexes show considerable cytotoxicity towards human cervical cancer cells (HeLa). The MTT assay suggested that, compared with complexes 1 and 2, complex 3 with lowest half maximum inhibitory concentration (IC50) is the most cytotoxic. In addition, the cytotoxicity was also confirmed by DAPI fluorescent staining method. The migration of HeLa cells is inhibited by NPs of the three complexes. The results showed that the NPs of complexes 1–3 can inhibit cell proliferation and migration in vitro.