SUMO and NF-κB ties

Members of the NF-κB family of transcription factors play critical roles in regulating immunity and cell survival and contribute to cancer progression and chemoresistance. Over the past 20 years, much has been learned about the remarkable complexity in regulation of NF-κB signaling. In particular, r...

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Bibliographic Details
Published inCellular and molecular life sciences : CMLS Vol. 64; no. 15; pp. 1979 - 1996
Main Authors Mabb, A. M, Miyamoto, S
Format Journal Article
LanguageEnglish
Published Basel Basel : Birkhäuser-Verlag 01.08.2007
Birkhäuser-Verlag
Subjects
IkappaBalpha
NEMO
NF-kappaB
PIAS
posttranslational
Review
SUMO
transcription
Ubc9
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Summary:Members of the NF-κB family of transcription factors play critical roles in regulating immunity and cell survival and contribute to cancer progression and chemoresistance. Over the past 20 years, much has been learned about the remarkable complexity in regulation of NF-κB signaling. In particular, recent studies have added to our current understanding of the roles of a multitude of posttranslational modifications in this signaling system: these include phosphorylation, acetylation, nitrosylation, ubiquitination, neddylation and sumoylation. This review will highlight our current knowledge of the roles of sumoylation in regulating NF-κB signaling and functions and will address future perspectives.
Bibliography:http://dx.doi.org/10.1007/s00018-007-7005-2
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-007-7005-2