Reductionism and proxy failure: From neuroscience to target-based drug discovery

Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge furthe...

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Bibliographic Details
Published inThe Behavioral and brain sciences Vol. 47; p. e83
Main Authors Sadri, Arash, Paknezhad, Sepideh
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 13.05.2024
Subjects
Approximation
Drug discovery
Drug Discovery - methods
Humans
Molecular biology
Neurosciences
Neurosciences - methods
Open Peer Commentary
Proteins
Reductionism
Online AccessGet full text
ISSN0140-525X
1469-1825
1469-1825
DOI10.1017/S0140525X23002893

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Summary:Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge further from the original object of study. We vividly illustrate this in the evolution of target-based drug discovery from rational and phenotypic drug discovery.
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ISSN:0140-525X
1469-1825
1469-1825
DOI:10.1017/S0140525X23002893