Bioprocess design : Study of a case

We developed a scale-up process design for the production of the 18 kDa heat shock recombinant protein from Mycobacterium leprae cloned in Saccharomyces cerevisiae. Here we present some of the costs associated with running a process based in our laboratory and pilot scale data. Based on these values...

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Bibliographic Details
Published inBiotechnology letters Vol. 18; no. 3; pp. 275 - 280
Main Authors SATO, R. A, BUENO DA COSTA, M. H
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 1996
Subjects
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Production of active biomolecules
Saccharomyces cerevisiae
Vaccins
Heterologous system
Yeast
Mycobacterium leprae
Purification
Process
Gene expression
Optimization
Fungi
Design
Dimensioning
Mycobacteriales
Heat shock protein
Mycobacteriaceae
Microorganism culture
Bacteria
Actinomycetes
Ascomycetes
Economic study
Recombinant protein
Cost analysis
Saccharomyces cerevisiae
Thallophyta
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Summary:We developed a scale-up process design for the production of the 18 kDa heat shock recombinant protein from Mycobacterium leprae cloned in Saccharomyces cerevisiae. Here we present some of the costs associated with running a process based in our laboratory and pilot scale data. Based on these values and assuming the demand of the 18kDa-hsp protein as 500g/year we can review costs at least on an approximate basis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0141-5492
1573-6776
DOI:10.1007/BF00142944