Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols

The preparation of palladium nanoparticles stabilized primarily within the protein cavity of a highly thermostable Dps protein (DNA binding protein from starved cells) and the use of this precatalyst system in Suzuki-Miyaura cross-coupling reactions under aerobic conditions in water is described, as...

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Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 11; no. 12; pp. 1929 - 1932
Main Authors Prastaro, A., Ceci, P., Chiancone, E., Boffi, A., Cirilli, R., Colone, M., Fabrizi, G., Stringaro, A., Cacchi, S.
Format Journal Article
LanguageEnglish
Published 01.01.2009
Subjects
Aerobic conditions
Alcohol
DNA
green development
Palladium
Proteins
Water wells
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Summary:The preparation of palladium nanoparticles stabilized primarily within the protein cavity of a highly thermostable Dps protein (DNA binding protein from starved cells) and the use of this precatalyst system in Suzuki-Miyaura cross-coupling reactions under aerobic conditions in water is described, as well as a two-step one-pot Suzuki-Miyaura cross-coupling followed by an enantioselective enzyme-catalyzed reduction to form chiral biaryl alcohols.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1463-9262
1463-9270
DOI:10.1039/b915184b