Coumarine based Cu(II) complex as chemosensor for selective detection of l-threonine and l-asparagine

[Display omitted] •3-AcetCuCl, a chemo sensor probe was prepared and characterised.•Amino acid sensing studies were done by using various l-aminoacids.•Highly selective sensing of l-Asparagine and l-Threonine were done by the probe.•The antiproliferative activity was evaluated against A549 and HT-29...

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Bibliographic Details
Published inInorganica Chimica Acta Vol. 526; p. 120525
Main Authors Sindhu, M., Kalaivani, P., Dallemer, F., Prabhakaran, R.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.10.2021
Elsevier Science Ltd
Subjects
3-Acetylcoumarine
Chemical sensors
Chemoreceptors
Colon
Cu(II) complex
Cytotoxicity
Fluorescence
l-Asparagine
l-Threonine
Toxicity
Cu(II) complex
Cytotoxicity
l-Threonine
3-Acetylcoumarine
l-Asparagine
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Summary:[Display omitted] •3-AcetCuCl, a chemo sensor probe was prepared and characterised.•Amino acid sensing studies were done by using various l-aminoacids.•Highly selective sensing of l-Asparagine and l-Threonine were done by the probe.•The antiproliferative activity was evaluated against A549 and HT-29 cell lines.•Assay on HEK cell lines showed that the compounds were non-toxic to those cells. A new probe [3-AcetCuCl] (where 3-Acet = 3-acetylcoumarine-4(N)-ethylthiosemicarbazone) has been designed and synthesized and it acts a selective and sensitive fluorescent “on–off” chemosensor for l-asparagine and l-threonine. The cytotoxicity of the probe and sensed compounds were studied against human lung cancer cell line (A549) and human colon cell line (HT-29) in which l-asparagine bounded probe showed better activity in both the cell lines than l-threonine bounded probe.
ISSN:0020-1693
1873-3255
DOI:10.1016/j.ica.2021.120525