MICROPARTICLES FOR STANDARDIZATION OF ELECTROPHORETIC DEVICES AND PROCESS CONTROL

An appreciation of the importance of particle surface charge as a determinant of the behavior of particle suspensions has stimulated interest in electrophoretic analyses of small particles. Currently available analytical particle electrophoresis equipment provide increasingly powerful techniques for...

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Bibliographic Details
Published inJournal of dispersion science and technology Vol. 19; no. 6-7; pp. 915 - 936
Main Authors Seaman, Geoffrey V.F., Knox, Robert J.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis Group 01.01.1998
Taylor & Francis
Subjects
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
General, apparatus, technics of preparation
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Validation
Surface charge
Process control
Device
Standardization
Micron size particle
Electrophoresis
Polymer
Manufacturing
Particle suspension
Application
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Summary:An appreciation of the importance of particle surface charge as a determinant of the behavior of particle suspensions has stimulated interest in electrophoretic analyses of small particles. Currently available analytical particle electrophoresis equipment provide increasingly powerful techniques for probing the surface charge of small particles so that the potential of the application of the method may be realized in basic and applied research as well as in process development and control in manufacturing environments. Two recurrent issues in the application of the methods are the qualification of the instrument operation and the consistency of the reagents employed. Here we describe strategies for addressing these problems through the use of uniform detergent free, charge-stabilized polymer microspheres first as control particles for monitoring satisfactory instrument operation and secondly as sensitive 'reporter" probes for detection of trace contaminants in the suspending media used for electrophoretie analysis.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932699808913223