Biomimetic fluorescent probe for chiral glutamic acid in water and its application in living cell imaging

•A BODIPY-based fluorescent probe for chiral amino acid of d-glutamic acid was developed.•The probe displays good selectivity for d-glutamic acid and its fluorescence enhance about 5 folds with good linear trend.•The probe realized the application in living cells for chiral amino acids. A BODIPY-bas...

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Bibliographic Details
Published inSensors and actuators. B, Chemical Vol. 320; p. 128383
Main Authors Zhao, Lei, Zhou, Hanxin, Zhou, Qinghai, Peng, Cheng, Cheng, Tanyu, Liu, Guohua
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier B.V 01.10.2020
Elsevier Science Ltd
Subjects
Amino acid
Biomimetics
BODIPY
Cells (biology)
Chiral sensing
D-glutamic acid
Fluorescent indicators
Fluorescent sensor
Glutamic acid
Metathesis
Selectivity
Chiral sensing
Fluorescent sensor
BODIPY
Amino acid
D-glutamic acid
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Summary:•A BODIPY-based fluorescent probe for chiral amino acid of d-glutamic acid was developed.•The probe displays good selectivity for d-glutamic acid and its fluorescence enhance about 5 folds with good linear trend.•The probe realized the application in living cells for chiral amino acids. A BODIPY-based fluorescent probe (PGA) for d-glutamic acid utilizing biomimetic imine metathesis reaction with pyridoxal-5′-phosphate and chiral 1,2-diaminocyclohexane as the detecting group. PGA displayed good selectivity and sensitivity for d-Glu in water. Moreover, PGA can image d-Glu in living cells.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2020.128383