High prevalence of occult hepatitis C virus infection in patients with chronic hepatitis B virus infection

Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients...

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Published inJournal of medical microbiology Vol. 62; no. 8; pp. 1235 - 1238
Main Authors CASTILLO, Inmaculada, BARTOLOME, Javier, QUIROGA, Juan Antonio, CARRENO, Vicente
Format Journal Article
LanguageEnglish
Published Reading Society for General Microbiology 01.08.2013
Subjects
Adult
Biological and medical sciences
DNA, Viral - blood
Female
Fundamental and applied biological sciences. Psychology
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis B Surface Antigens - analysis
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - virology
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C - virology
Human viral diseases
Humans
In Situ Hybridization
Infectious diseases
Liver - enzymology
Liver - virology
Liver Cirrhosis - complications
Liver Cirrhosis - immunology
Liver Cirrhosis - virology
Male
Medical sciences
Microbiology
Prevalence
Real-Time Polymerase Chain Reaction
RNA, Viral - blood
Viral diseases
Viral hepatitis
Infection
Human
Viral hepatitis B
Prevalence
Viral disease
Digestive diseases
Hepatic disease
Epidemiology
Viral hepatitis C
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Summary:Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients with chronic HBV infection and 21 (40 %) of them were positive for viral RNA (occult HCV infection). Liver fibrosis was found more frequently and the fibrosis score was significantly higher in patients with occult HCV than in negative ones, suggesting that occult HCV infection may have an impact on the clinical course of HBV infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-2615
1473-5644
DOI:10.1099/jmm.0.058297-0