Transfer RNA and transfer RNA methylase activity in spleens of patients with Hodgkin's disease and histiocytic lymphoma

tRNA levels, base composition, and tRNA methylase activities of normal and tumor tissue from the spleens of 24 patients (18 with Hodgkin's disease and 6 with histiocytic lymphoma) were studied. There were no significant differences in major base composition of normal and tumor tissue. Methylate...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 56; no. 2; p. 215
Main Authors Murphy, T L, Cooper, I A, Wray, G W, Ironside, P N, Matthews, J
Format Journal Article
LanguageEnglish
Published United States 01.02.1976
Subjects
Hodgkin Disease - metabolism
Humans
Lymphoma, Large B-Cell, Diffuse - metabolism
Purines - analysis
Purines - urine
Pyrimidines - analysis
Pyrimidines - urine
RNA, Transfer - analysis
Spleen - analysis
Spleen - metabolism
tRNA Methyltransferases - metabolism
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Summary:tRNA levels, base composition, and tRNA methylase activities of normal and tumor tissue from the spleens of 24 patients (18 with Hodgkin's disease and 6 with histiocytic lymphoma) were studied. There were no significant differences in major base composition of normal and tumor tissue. Methylated guanosine was increased in tumor tissue of some patients, and tRNA methylase activities were increased in extracts from the tumors.
ISSN:0027-8874
DOI:10.1093/jnci/56.2.215