Bleomycin-induced pulmonary nodules: A variant of bleomycin pulmonary toxicity

Bleomycin has been associated with pulmonary toxicity which is typically manifested as an interstitial pneumonitis resulting in fine, diffuse reticular or reticulomicronodular infiltrates. Attention is drawn to an additional radiologic appearance where discrete pulmonary nodules are seen and represe...

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Bibliographic Details
Published inGynecologic oncology Vol. 28; no. 3; pp. 284 - 291
Main Authors Zucker, Peter K., Khouri, Nagi F., Rosenshein, Neil B.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.11.1987
Elsevier
Subjects
Adolescent
Biological and medical sciences
Bleomycin - adverse effects
Bleomycin - therapeutic use
Drug toxicity and drugs side effects treatment
Female
Humans
Lung - diagnostic imaging
Lung Diseases - chemically induced
Lung Diseases - diagnostic imaging
Medical sciences
Neoplasms, Germ Cell and Embryonal - drug therapy
Ovarian Neoplasms - drug therapy
Pharmacology. Drug treatments
Radiography
Toxicity: respiratory system, ent, stomatology
Human
Antineoplastic agent
Respiratory disease
Toxicity
Lung
Adolescent
Nodule
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Summary:Bleomycin has been associated with pulmonary toxicity which is typically manifested as an interstitial pneumonitis resulting in fine, diffuse reticular or reticulomicronodular infiltrates. Attention is drawn to an additional radiologic appearance where discrete pulmonary nodules are seen and representative of bleomycin-induced change. The pitfalls of interpreting such changes as toxic effects versus metastatic disease and proposed mechanisms of bleomycin pulmonary toxicity are discussed.
ISSN:0090-8258
1095-6859
DOI:10.1016/0090-8258(87)90174-0