Biomedical overview of melanin. 2. Updating molecular modeling, synthesis mechanism, and supramolecular properties regarding melanoma therapy

Melanins represent one of the most ancient and important group of natural macromolecular pigments. They have multiple biological roles in almost all organisms across the Phyla, examples being photoprotection, anti-oxidative action, radical scavenger activity, and heavy metal removal. From the biomed...

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Published inBiocell Vol. 46; no. 6; pp. 1391 - 1415
Main Authors CARLOS STOCKERT, JUAN, BL罿QUEZ-CASTRO, ALFONSO
Format Journal Article
LanguageEnglish
Published Mendoza Tech Science Press 2022
Subjects
Heavy metals
Macromolecules
Melanin
Melanocytes
Melanoma
Molecular modelling
Pigments
Tumors
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Summary:Melanins represent one of the most ancient and important group of natural macromolecular pigments. They have multiple biological roles in almost all organisms across the Phyla, examples being photoprotection, anti-oxidative action, radical scavenger activity, and heavy metal removal. From the biomedical point of view, melanocytes are involved in the origin of melanoma tumors, and the main therapeutic advances for their treatment have been revised in Part 1 of this review. The chemical structure of eumelanin is a biological concern of great importance, and therefore, exploring theoretical molecular models and synthesis mechanisms will be here described, as well as molecular orbital features and supramolecular organization, which are responsible for the key properties that make these biological pigments so important, and so fascinating. Ultimately, this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin, in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.
ISSN:1667-5746
0327-9545
DOI:10.32604/biocell.2022.019493