Virus fitness: concept, quantification, and application to HIV population dynamics

Viral fitness has been broadly studied during the past three decades, mainly to test evolutionary models and population theories difficult to analyze and interpret with more complex organisms. More recent studies, however, are focused in the role of fitness on viral transmission, pathogenesis, and d...

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Bibliographic Details
Published inCurrent topics in microbiology and immunology Vol. 299; p. 83
Main Authors Quiñones-Mateu, M E, Arts, E J
Format Journal Article
LanguageEnglish
Published Germany 2006
Subjects
Anti-HIV Agents - pharmacology
Disease Progression
Drug Resistance, Viral
Evolution, Molecular
Genetic Variation
HIV - drug effects
HIV - genetics
HIV - growth & development
HIV - pathogenicity
Mutation
Virus Replication
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Summary:Viral fitness has been broadly studied during the past three decades, mainly to test evolutionary models and population theories difficult to analyze and interpret with more complex organisms. More recent studies, however, are focused in the role of fitness on viral transmission, pathogenesis, and drug resistance. Here, we used human immunodeficiency virus (HIV) as one of the most relevant models to evaluate the importance of viral quasispecies and fitness in HIV evolution, population dynamics, disease progression, and potential clinical implications.
ISSN:0070-217X
DOI:10.1007/3-540-26397-7_4