Ready-to-use single-strip paper based sensor for multiplex ion detection

[Display omitted] •Traditional pre-conditioning step protocols for solid-contact ion-selective electrode were avoided.•For the first time, re-usable and flexible paper-based sensors with sub-micromolar limit of detection for ions are reported.•The ion-selective electrodes and the reference electrode...

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Bibliographic Details
Published inSensors and actuators. B, Chemical Vol. 255; pp. 1781 - 1787
Main Authors Armas, Stephanie M., Manhan, Andrew J., Younce, Olivia, Calvo-Marzal, Percy, Chumbimuni-Torres, Karin Y.
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier B.V 01.02.2018
Elsevier Science Ltd
Subjects
Biosensors
Conditioning
Electrodes
Ion detectors
Ion-selective electrodes
Ionic liquids
Multiplex detection
Multiplexing
Polymethyl methacrylate
Portable equipment
Single-strip
Solid contact paper-based sensors
Strip
Ion-selective electrodes
Single-strip
Solid contact paper-based sensors
Multiplex detection
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Summary:[Display omitted] •Traditional pre-conditioning step protocols for solid-contact ion-selective electrode were avoided.•For the first time, re-usable and flexible paper-based sensors with sub-micromolar limit of detection for ions are reported.•The ion-selective electrodes and the reference electrode were integrated in a single-strip format. Ion-selective electrodes (ISEs) are an efficient and versatile tool for ion detection. However, portability and applicability for field applications are often limited by the need of a conditioning step, and high cost of the needed bulky reference electrode. Herein, the traditional conditioning protocol of ISEs has been eliminated and a paper-based solid-contact ISE (PBSC-ISE) has been integrated with a paper-based solid-contact reference electrode (PBSC-RE) in a single strip format for on-site analysis. The PBSC-RE is based on the copolymer methyl methacrylate-co-decyl methacrylate (MMA-DMA) (support matrix), combined with ionic liquids (ILs) to create and maintain a stable potential that is un-affected by a change in ionic activity. This single-strip ready-to-use sensor yields a Nernstian response towards Na+, K+, and I− ions with submicromolar limits of detection, and is able to be used for multiplex analysis.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2017.08.194