New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes

The cytotoxicity of 18 new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides was evaluated. This group of products was previously assayed against epimastigotes of Trypanosoma cruzi and some of them showed a high antiprotozoal activity. Thereafter 13 compounds with a high anti-epimastigote activity and low cyt...

Full description

Saved in:
Bibliographic Details
Published inFolia parasitologica Vol. 48; no. 2; pp. 105 - 108
Main Authors Muelas, S, Di Maio, R, Cerecetto, H, Seoane, G, Ochoa, C, Escario, J A, Gómez-Barrio, A
Format Journal Article
LanguageEnglish
Published Czech Republic 01.01.2001
Subjects
Animals
Antiprotozoal Agents - pharmacology
Chagas Disease - drug therapy
Macrophages - drug effects
Macrophages - parasitology
Mice
Parasitic Sensitivity Tests
Thiadiazines - pharmacology
Trypanosoma cruzi - drug effects
Online AccessGet full text

Cover

More Information
Summary:The cytotoxicity of 18 new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides was evaluated. This group of products was previously assayed against epimastigotes of Trypanosoma cruzi and some of them showed a high antiprotozoal activity. Thereafter 13 compounds with a high anti-epimastigote activity and low cytotoxicity were selected to be assayed against amastigotes. Some of the products showed the same or even lower cytotoxicity than nifurtimox and benznidazole, but most of them were very toxic for macrophages at 100 microg/ml. Only one of the compounds had an anti-amastigote activity similar to that of reference drugs at 10 microg/ml, but unfortunately this disappeared at lower concentrations.
ISSN:0015-5683
1803-6465
DOI:10.14411/fp.2001.015