Effect of (+-)-, (+)- and (-)-gossypol on the lactate dehydrogenase-X activity of rat testis

The effect of (+/-)-, (+)- and (-)-gossypol on testicular lactate dehydrogenase-X (LDH-X) was studied in vitro and in vivo. It was found that racemic gossypol and the two optical enantiomers had similar inhibitory effects on rat testicular LDH-X in vitro. However, neither racemic gossypol nor the en...

Full description

Saved in:
Bibliographic Details
Published inJournal of ethnopharmacology Vol. 20; no. 1; pp. 25 - 29
Main Authors Yao, K.Q, Gu, Q.M, Lei, H.P
Format Journal Article
LanguageEnglish
Published Ireland 01.06.1987
Subjects
Animals
enzyme activity
gossypol
Gossypol - pharmacology
Isoenzymes
L-Lactate Dehydrogenase - antagonists & inhibitors
lactate dehydrogenase
Male
Rats
Stereoisomerism
testes
Testis - drug effects
Testis - enzymology
Online AccessGet more information

Cover

More Information
Summary:The effect of (+/-)-, (+)- and (-)-gossypol on testicular lactate dehydrogenase-X (LDH-X) was studied in vitro and in vivo. It was found that racemic gossypol and the two optical enantiomers had similar inhibitory effects on rat testicular LDH-X in vitro. However, neither racemic gossypol nor the enantiomers exhibited an inhibitory effect on testicular LDH-X in vivo. It is concluded that inhibition of testicular LDH-X is not likely to be the mechanism of the antifertility action of gossypol. The inhibition of testicular LDH-X in vitro by all three preparations of gossypol is probably non-specific.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(87)90115-2