A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C⋅G Interruption by Triplex Formation with a Pyrimidine Motif
Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2‐pyridone and a 2′‐O,4′‐C‐methylene‐bridged nucleic acid analogue (PB, see picture). The degree of stabilization of the triplex formed enables C⋅G interrupti...
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Published in | Angewandte Chemie (International ed.) Vol. 40; no. 11; pp. 2079 - 2081 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Weinheim
WILEY-VCH Verlag GmbH
01.06.2001
WILEY‐VCH Verlag GmbH |
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Abstract | Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2‐pyridone and a 2′‐O,4′‐C‐methylene‐bridged nucleic acid analogue (PB, see picture). The degree of stabilization of the triplex formed enables C⋅G interruptions in a homopurine⋅homopyrimidine double‐stranded DNA to be detected. |
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AbstractList | Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a 2'-O,4'-C-methylene-bridged nucleic acid analogue (PB , see picture). The degree of stabilization of the triplex formed enables C⋅G interruptions in a homopurine⋅homopyrimidine double-stranded DNA to be detected. Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a 2'-O,4'-C-methylene-bridged nucleic acid analogue (P , see picture). The degree of stabilization of the triplex formed enables C⋅G interruptions in a homopurine⋅homopyrimidine double-stranded DNA to be detected. |
Author | Obika, Satoshi Imanishi, Takeshi Sekiguchi, Mitsuaki Hari, Yoshiyuki |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29712196$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S0040-4039(98)00706-0 10.1039/a900458k 10.1039/a708608c 10.1093/nar/19.7.1521 10.1074/jbc.M007783200 10.1016/S0223-5234(98)80016-0 10.1039/cs9972600063 10.1016/S0040-4039(00)01607-5 10.1093/nar/22.15.3233 10.1073/pnas.89.9.3840 10.1016/S0960-894X(99)00451-5 10.1016/S0040-4039(97)10322-7 10.5059/yukigoseikyokaishi.57.969 10.1093/nar/18.22.6621 |
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Notes | ArticleID:ANIE2079 ark:/67375/WNG-DVP1S16D-5 istex:B73D18E763561B79A65B1888903FF38CD4CCB8E4 Part of this work was supported by a Grant‐in‐Aid for Scientific Research (B) (No. 12557201) from the Japan Society for the Promotion of Science. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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Snippet | Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2‐pyridone and a... Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a... |
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Title | A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C⋅G Interruption by Triplex Formation with a Pyrimidine Motif |
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