A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C⋅G Interruption by Triplex Formation with a Pyrimidine Motif

Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2‐pyridone and a 2′‐O,4′‐C‐methylene‐bridged nucleic acid analogue (PB, see picture). The degree of stabilization of the triplex formed enables C⋅G interrupti...

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Published inAngewandte Chemie (International ed.) Vol. 40; no. 11; pp. 2079 - 2081
Main Authors Obika, Satoshi, Hari, Yoshiyuki, Sekiguchi, Mitsuaki, Imanishi, Takeshi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 01.06.2001
WILEY‐VCH Verlag GmbH
Subjects
DNA recognition
nucleic acids
nucleobases
oligonucleotides
DNA recognition
nucleic acids
oligonucleotides
nucleobases
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Abstract Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2‐pyridone and a 2′‐O,4′‐C‐methylene‐bridged nucleic acid analogue (PB, see picture). The degree of stabilization of the triplex formed enables C⋅G interruptions in a homopurine⋅homopyrimidine double‐stranded DNA to be detected.
AbstractList Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a 2'-O,4'-C-methylene-bridged nucleic acid analogue (PB , see picture). The degree of stabilization of the triplex formed enables C⋅G interruptions in a homopurine⋅homopyrimidine double-stranded DNA to be detected.
Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a 2'-O,4'-C-methylene-bridged nucleic acid analogue (P , see picture). The degree of stabilization of the triplex formed enables C⋅G interruptions in a homopurine⋅homopyrimidine double-stranded DNA to be detected.
Author Obika, Satoshi
Imanishi, Takeshi
Sekiguchi, Mitsuaki
Hari, Yoshiyuki
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10.1016/S0040-4039(97)10322-7
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Keywords DNA recognition
nucleic acids
oligonucleotides
nucleobases
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Part of this work was supported by a Grant‐in‐Aid for Scientific Research (B) (No. 12557201) from the Japan Society for the Promotion of Science.
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  ident: 10.1002/1521-3773(20010601)40:11<2079::AID-ANIE2079>3.0.CO;2-Z-BIB6
  publication-title: J. Synth. Org. Chem. Jpn.
  doi: 10.5059/yukigoseikyokaishi.57.969
  contributor:
    fullname: Imanishi
– volume: 18
  start-page: 6621
  year: 1990
  ident: 10.1002/1521-3773(20010601)40:11<2079::AID-ANIE2079>3.0.CO;2-Z-BIB12
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/18.22.6621
  contributor:
    fullname: Belotserkovskii
SSID ssj0028806
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Snippet Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2‐pyridone and a...
Significantly enhanced binding affinity to C⋅G base pairs without loss of sequence selectivity is achieved by using a nucleotide containing a 2-pyridone and a...
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SubjectTerms DNA recognition
nucleic acids
nucleobases
oligonucleotides
Title A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C⋅G Interruption by Triplex Formation with a Pyrimidine Motif
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https://www.ncbi.nlm.nih.gov/pubmed/29712196
https://search.proquest.com/docview/2033379118
Volume 40
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