Chemical properties and anti-complementary activities of heteroglycans from the leaves of Panax ginseng

Four anti-complementary neutral (GL-NIa and GL-NIb) and acidic (GL-AIa and GL-AIb) polysaccharides were purified from the leaves of Panax ginseng C. A. Meyer. Only GL-NIa and GL-AIa exhibited potent anti-complementary activities at low concentrations probably through the alternative complement pathw...

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Bibliographic Details
Published inPlanta medica Vol. 57; no. 2; pp. 132 - 136
Main Authors Gao, Q.P, Kiyohara, H, Cyong, J.C, Yamada, H
Format Journal Article
LanguageEnglish
Published Germany 01.04.1991
Subjects
anti-complementary activity
Carbohydrate Sequence
Carbohydrates - analysis
complement
Complement Inactivator Proteins - chemistry
Complement Inactivator Proteins - isolation & purification
leaves
Molecular Sequence Data
Panax - analysis
Panax pseudoginseng
plant extracts
Plants, Medicinal
polysaccharides
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
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Summary:Four anti-complementary neutral (GL-NIa and GL-NIb) and acidic (GL-AIa and GL-AIb) polysaccharides were purified from the leaves of Panax ginseng C. A. Meyer. Only GL-NIa and GL-AIa exhibited potent anti-complementary activities at low concentrations probably through the alternative complement pathway. Glycosyl linkage analysis demonstrated that GL-NIa mainly consisted of arabinogalactan moieties, whereas GL-NIb contained large amounts of (1---4)-linked glucosyl residues. Beta-Elimination indicated that GL-AIa and GL-AIb were pectic polysaccharides consisting of a rhamnogalacturonan core with neutral side chains. GL-AIa reacted strongly with beta-glucosyl-Yariv antigen, GL-NIa reacted weakly, whereas GL-NIb and GL-AIb showed no reaction with the antigen.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-960049