Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum

• Published in: BJU international Vol. 87; no. 3; pp. 265 - 268
• Main Authors: Ayan, S., Sarioglu, Y., Yildirim, S., Gökce, G., Bagcivan, I.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.02.2001; Blackwell
• Subjects: Animals; Biological and medical sciences; corpus cavernosum; diabetes mellitus; Diabetes Mellitus, Experimental - physiopathology; Dose-Response Relationship, Drug; Enzyme Inhibitors - pharmacology; erectile dysfunction; Erectile Dysfunction - physiopathology; Genital system. Reproduction; Male; Medical sciences; Muscle Relaxation - drug effects; Muscle, Smooth - drug effects; omeprazole; Omeprazole - pharmacology; Penis - drug effects; Penis - physiology; Pharmacology. Drug treatments; Rabbits; Endocrinopathy; Animal model; Erection disorders; Enzyme; Impotence; Diabetes mellitus; Treatment efficiency; H; Enzyme inhibitor; Rabbit; K; Lagomorpha; Omeprazole; Vertebrata; Chemotherapy; Mammalia; Benzimidazole derivatives; Animal; Hydrolases; exchanging ATPase; Male genital diseases

Objective To investigate the changes in relaxation responses to omeprazole in corpus cavernosal strips from rabbits with diabetes induced by alloxan. Materials and methods Diabetes was induced in 10 New Zealand white rabbits. After 8 weeks, the reactivity to electrical‐field stimulation, carbachol a...