Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum

Objective To investigate the changes in relaxation responses to omeprazole in corpus cavernosal strips from rabbits with diabetes induced by alloxan. Materials and methods Diabetes was induced in 10 New Zealand white rabbits. After 8 weeks, the reactivity to electrical‐field stimulation, carbachol a...

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Bibliographic Details
Published inBJU international Vol. 87; no. 3; pp. 265 - 268
Main Authors Ayan, S., Sarioglu, Y., Yildirim, S., Gökce, G., Bagcivan, I.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.02.2001
Blackwell
Subjects
Animals
Biological and medical sciences
corpus cavernosum
diabetes mellitus
Diabetes Mellitus, Experimental - physiopathology
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
erectile dysfunction
Erectile Dysfunction - physiopathology
Genital system. Reproduction
Male
Medical sciences
Muscle Relaxation - drug effects
Muscle, Smooth - drug effects
omeprazole
Omeprazole - pharmacology
Penis - drug effects
Penis - physiology
Pharmacology. Drug treatments
Rabbits
Endocrinopathy
Animal model
Erection disorders
Enzyme
Impotence
Diabetes mellitus
Treatment efficiency
H
Enzyme inhibitor
Rabbit
K
Lagomorpha
Omeprazole
Vertebrata
Chemotherapy
Mammalia
Benzimidazole derivatives
Animal
Hydrolases
exchanging ATPase
Male genital diseases
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Summary:Objective To investigate the changes in relaxation responses to omeprazole in corpus cavernosal strips from rabbits with diabetes induced by alloxan. Materials and methods Diabetes was induced in 10 New Zealand white rabbits. After 8 weeks, the reactivity to electrical‐field stimulation, carbachol and omeprazole of corporal strips from the penises of the diabetic animals and from 10 untreated controls was assessed in organ chambers. Results In the diabetic group, the relaxation responses of corpus cavernosal strips to omeprazole were comparable with those of the control group, whereas the relaxation responses to electrical field stimulation and carbachol were impaired. Conclusion The relaxant effect of omeprazole in corpus cavernosum was not affected by diabetes, in which neurogenic and endothelium‐mediated relaxations were impaired.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1464-4096
1464-410X
DOI:10.1046/j.1464-410x.2001.02037.x