High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

ABSTRACT Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A to...

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Published inBioFactors (Oxford) Vol. 45; no. 3; pp. 335 - 342
Main Authors Tavakoli, Hamidreza, Rostami, Hossein, Avan, Amir, Bagherniya, Mohammad, Ferns, Gordon A., Khayyatzadeh, Sayyed Saeid, Ghayour‐Mobarhan, Majid
Format Journal Article
LanguageEnglish
Published Netherlands 01.05.2019
Subjects
Adolescent
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Anthropometry
Aspartate Aminotransferases - blood
Bilirubin - blood
Biomarkers - blood
Child
Female
gamma-Glutamyltransferase - blood
Humans
L-Lactate Dehydrogenase - blood
liver
Liver - metabolism
Liver Diseases - blood
Liver Function Tests
supplementation
vitamin D
Vitamin D - therapeutic use
supplementation
adolescent
liver
vitamin D
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Summary:ABSTRACT Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma‐glutamyl transferase (ϒGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls. Significant reductions were observed for AST, ALT, direct bilirubin, total bilirubin, LDH, and ϒGT at the end of supplementation, only in the group with abnormal reference value. Serum levels of total protein and albumin were higher at the end of follow up in the group with abnormal value. No significant change was obtained for LFTs in the group with normal value. Our findings suggest that vitamin D supplementation may improve markers of liver function in adolescents with abnormal LFTs. More randomized controlled trial with longer follow‐up time will be required. © 2019 BioFactors, 45(3):335–342, 2019
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ISSN:0951-6433
1872-8081
1872-8081
DOI:10.1002/biof.1496