Distribution of the HLA‐DPB1 alleles in a Russian population living in the Chelyabinsk region (South Ural of Russia)

The purpose of this work was to establish the distribution of HLA‐DPB1 alleles in Russians living in the Chelyabinsk region (Russia). DPB1 frequencies were determined in 100 unrelated Russian, living in the Chelyabinsk region. All subjects were healthy unrelated blood donors, between 18 and 55 years...

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Bibliographic Details
Published inHLA Vol. 94; no. S2; pp. 34 - 39
Main Authors Burmistrova, Alexandra L., Vavilov, Mikhail N., Khromova, Elena B., Suslova, Tatiana A.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.12.2019
Subjects
Adolescent
Adult
Alleles
Blood Donors - statistics & numerical data
Female
gene frequencies
Gene Frequency
Genetics, Population
HLA-DP beta-Chains - genetics
HLA‐DPB1
Humans
Male
Middle Aged
NGS
Polymorphism, Genetic
population
Russia - epidemiology
Young Adult
Russia
HLA-DPB1
NGS
gene frequencies
population
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Summary:The purpose of this work was to establish the distribution of HLA‐DPB1 alleles in Russians living in the Chelyabinsk region (Russia). DPB1 frequencies were determined in 100 unrelated Russian, living in the Chelyabinsk region. All subjects were healthy unrelated blood donors, between 18 and 55 years of age. Typing was performed by NGS (DNA‐technology, Moscow). For population genetics analysis GENE[RATE] (https://hla-net.eu/tools/) software was used. DPB1*04:01 prevails in this population (gf = 0.3667). Other frequent HLA‐DPB1 alleles were: DPB1*04:02, DPB1*02:01, DPB1*03:01 (gf = 0.1490; 0.1481; 0.1385, respectively). Rare alleles (gf ≤ 0.03) were DPB1*17:01, DPB1*01:01, DPB1*06:01, DPB1*14:01, DPB1*05:01, DPB1*13:01, DPB1*09:01, DPB1*10:01, DPB1*11:01, DPB1*23:01, DPB1*124:01, DPB1*15:01, DPB1*16:01, DPB1*105:01, DPB1*150:01.
ISSN:2059-2302
2059-2310
DOI:10.1111/tan.13765