Pretreatment leukocyte ratios and concentrations as predictors of outcome in dogs with cutaneous mast cell tumours

• Published in: Veterinary & comparative oncology Vol. 15; no. 4; pp. 1333 - 1345
• Main Authors: Skor, O., Fuchs‐Baumgartinger, A., Tichy, A., Kleiter, M., Schwendenwein, I.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2017
• Subjects: Animals; Dog Diseases - blood; Dog Diseases - diagnosis; Dog Diseases - immunology; Dog Diseases - mortality; Dogs; eosinophilia; Female; Leukocyte Count - veterinary; lymphocyte‐to‐monocyte ratio; Male; Mastocytosis - blood; Mastocytosis - diagnosis; Mastocytosis - immunology; Mastocytosis - veterinary; monocytosis; neutrophil‐to‐eosinophil ratio; neutrophil‐to‐lymphocyte ratio; Prognosis; Skin Diseases - veterinary; Survival Analysis; eosinophilia; neutrophil-to-lymphocyte ratio; monocytosis; prognosis; lymphocyte-to-monocyte ratio; neutrophil-to-eosinophil ratio
• ISSN: 1476-5810; 1476-5829
• DOI: 10.1111/vco.12274

Leukocyte ratios correlate with outcome in several human cancers. Little is known about their prognostic significance in mast cell tumour (MCT). The aim of the study was to evaluate the prognostic significance of pretreatment leukocyte concentrations and their ratios in dogs with MCT for survival. Medical records of 92 dogs with MCT were retrospectively reviewed. Tumour diagnosis was made by tumour biopsy or fine‐needle aspirate. Only dogs without prior treatment were included. Eosinophil, lymphocyte, monocyte and neutrophil concentration were obtained by ADVIA 2120™ (Siemens Healthcare, Vienna, Austria). Neutrophil‐to‐eosinophil ratio (NER), lymphocyte‐to‐monocyte ratio (LMR) and neutrophil‐to‐lymphocyte ratio (NLR) were calculated from collected leukocyte concentrations. Relative eosinophil concentration (REC), NER (P < 0.001), NLR (P = 0.001) and LMR (P < 0.001) were significant prognostic factors for outcome in univariate analysis. REC (P = 0.008) and NER (P = 0.001) remained independent predictors of survival in multiple analyses. Leukocyte concentrations and ratios, especially REC and NER may serve as prognostic indicators in MCT.