EVALUATION OF THE NEUROVIRULENCE TEST OF ORAL POLIOVACCINES IN JAPAN DURING THE PERIOD 1963-1982

The present study showed that the neurovirulence test for the lesioninducing virus dose in the spinal cord in 50% of monkeys inoculated with oral poliovaccine (Sabin) (LID50) reflected to a large extent safety and efficacy of the vaccine upon administration to children. The degree of attenuation of...

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Bibliographic Details
Published inJapanese Journal of Medical Science and Biology Vol. 37; no. 5-6; pp. 233 - 240
Main Authors CHINO, Fumitoshi, KODAMA, Hideo, HARA, Minoru, KOMATSU, Toshihiko
Format Journal Article
LanguageEnglish
Published Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 1984
Subjects
Animals
Child
Drug Evaluation, Preclinical
Humans
Japan
Macaca fascicularis
Poliomyelitis - etiology
Poliovirus Vaccine, Oral - adverse effects
Poliovirus Vaccine, Oral - isolation & purification
Poliovirus Vaccine, Oral - toxicity
Japan
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Summary:The present study showed that the neurovirulence test for the lesioninducing virus dose in the spinal cord in 50% of monkeys inoculated with oral poliovaccine (Sabin) (LID50) reflected to a large extent safety and efficacy of the vaccine upon administration to children. The degree of attenuation of the vaccine in terms of LID50 appeared to be related to the decrease in the vaccine-associated cases as well as the seroconversion rate. An exceptional case, however, was noted in which lot No. 301 was not classified into less attenuated vaccine by the neurovirulence test. This fact suggests that the method we have employed awaits further improvement.
ISSN:0021-5112
1884-2828
DOI:10.7883/yoken1952.37.233