Risk of malignancy in patients with psoriasis: a 15‐year nationwide population‐based prospective cohort study in Korea
Background The association between psoriasis and risk of malignancy has not been thoroughly evaluated in a large longitudinal cohort of Asian population. Objective To determine the long‐term risk of malignancy in Korean adult patients with psoriasis. Methods We conducted a nationwide population‐base...
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Published in | Journal of the European Academy of Dermatology and Venereology Vol. 33; no. 12; pp. 2296 - 2304 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.12.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Background
The association between psoriasis and risk of malignancy has not been thoroughly evaluated in a large longitudinal cohort of Asian population.
Objective
To determine the long‐term risk of malignancy in Korean adult patients with psoriasis.
Methods
We conducted a nationwide population‐based prospective cohort study with a 15‐year observational period. During the baseline period (1997–2000), total 1 773 786 Korean subjects who received health insurance from the National Health Insurance System were enrolled and 5788 subjects were defined as a psoriasis group. The number of new‐onset malignancy was collected during the observational period (2001–2015).
Results
Patients with psoriasis had a higher adjusted hazard ratio (aHR) for development of overall malignancy [aHR 1.08, 95% confidence interval (CI) 1.00–1.18] and gastric cancer (aHR 1.31, 95% CI 1.08–1.58) compared to controls. The risks of non‐Hodgkin lymphoma and non‐melanoma skin cancer were significantly increased only in patients with psoriasis who received systemic treatments (aHR 2.86, 95% CI 1.07–7.61 and aHR 3.93, 95% CI 1.47–10.47, respectively).
Conclusion
Psoriasis is associated with long‐term risk for overall malignancy in Koreans, which was primarily driven by the increased risk of gastric cancer. |
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Bibliography: | Funding sources This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health ndustry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (HI17C1659 to MGL; HI14C2686 to SHJ), by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2017R1D1A1B03035571 to TGK; NRF‐2016R1A6A3A11933465 to KJJ), and by the NRF grant funded by the Korea government (Ministry of Science and ICT) (NRF‐2018R1A2B6007818 to MGL). Co‐first authors. Conflict of interest None declared. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0926-9959 1468-3083 |
DOI: | 10.1111/jdv.15783 |