Serum levels of AGGF1: Potential association with cutaneous and cardiopulmonary involvements in systemic sclerosis

• Published in: Journal of dermatology Vol. 51; no. 8; pp. 1083 - 1090
• Main Authors: Takahashi, Takuya, Takahashi, Takehiro, Ikawa, Tetsuya, Terui, Hitoshi, Takahashi, Toshiya, Segawa, Yuichiro, Sumida, Hayakazu, Yoshizaki, Ayumi, Sato, Shinichi, Asano, Yoshihide
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2024
• Subjects: Adult; Aged; AGGF1; Angiogenesis; Angiogenic Proteins - blood; Autoimmune diseases; C-Reactive Protein - analysis; Carbon monoxide; Case-Control Studies; Cross-Sectional Studies; Echocardiography; Endothelial cells; Female; Fibrosis; Forkhead protein; Heart; Humans; Immune response; interstitial lung disease; Male; Middle Aged; Mucin-1 - blood; Pathogenesis; Protein D; Scleroderma; Scleroderma, Systemic - blood; Scleroderma, Systemic - complications; Scleroderma, Systemic - immunology; Serum levels; Severity of Illness Index; Skin - pathology; Skin diseases; Skin Ulcer - blood; Skin Ulcer - diagnosis; Skin Ulcer - etiology; Skin Ulcer - pathology; Surfactant protein D; Systemic sclerosis; Ulcers; Vascular diseases; vasculopathy; Vital Capacity; AGGF1; fibrosis; systemic sclerosis; vasculopathy; interstitial lung disease
• ISSN: 0385-2407; 1346-8138; 1346-8138
• DOI: 10.1111/1346-8138.17233

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G‐patch domain and a Forkhead‐associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients. We conducted a cross‐sectional analysis of AGGF1 levels in sera from 60 SSc patients and 19 healthy controls with enzyme‐linked immunosorbent assay. Serum AGGF1 levels in SSc patients were significantly higher than those in healthy individuals. In particular, diffuse cutaneous SSc patients with shorter disease duration had higher levels compared to those with longer disease duration and limited cutaneous SSc patients. Patients with higher serum AGGF1 levels had a higher incidence of digital ulcers, higher modified Rodnan Skin Scores (mRSS), elevated serum Krebs von den Lungen‐6 (KL‐6) levels, C‐reactive protein levels, and right ventricular systolic pressures (RVSP) on the echocardiogram, whereas they had reduced percentage of vital capacity (%VC) and percentage of diffusing capacity of the lungs for carbon monoxide (%DLCO) in pulmonary functional tests. In line, serum AGGF1 levels were significantly correlated with mRSS, serum KL‐6 and surfactant protein D levels, RVSP, and %DLCO. These results uncovered notable correlations between serum AGGF1 levels and key cutaneous and vascular involvements in SSc, suggesting potential roles of AGGF1 in SSc pathogenesis.