Recent Advances in the Total Synthesis of Piperidine and Pyrrolidine Natural Alkaloids with Ring-Closing Metathesis as a Key Step

This microreview focuses on recent applications of the ring‐closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids. The most recent examples are described, from simple piperidine alkaloids to complex pentacyclic structures such as...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2003; no. 19; pp. 3693 - 3712
Main Authors Felpin, François-Xavier, Lebreton, Jacques
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.10.2003
WILEY‐VCH Verlag
Subjects
Alkaloids
Cyclization
Metathesis
Total synthesis
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Summary:This microreview focuses on recent applications of the ring‐closing metathesis reaction (RCM) to construct piperidine and pyrrolidine cores for the total synthesis of natural alkaloids. The most recent examples are described, from simple piperidine alkaloids to complex pentacyclic structures such as (+)‐tabersonine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Bibliography:istex:EE059E00FB29AF1E5193084BB8B17B2A50A64A8B
ark:/67375/WNG-T06QF3Z7-9
ArticleID:EJOC200300193
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200300193