CD30+ lymphoproliferative disorder with spindle‐cell morphology

• Published in: Journal of cutaneous pathology Vol. 43; no. 11; pp. 1041 - 1044
• Main Authors: Martires, Kathryn J., Cohen, Brandon E., Cassarino, David S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2016
• Subjects: Aged, 80 and over; CD30 positive lymphoproliferative disorder; Female; Humans; Ki-1 Antigen - metabolism; lymphomatoid papulosis; Lymphomatoid Papulosis - diagnosis; Lymphomatoid Papulosis - immunology; primary cutaneous anaplastic large cell lymphoma; primary cutaneous lymphoproliferative disease; Skin Neoplasms - diagnosis; Skin Neoplasms - immunology; spindle cells; lymphomatoid papulosis; spindle cells; primary cutaneous lymphoproliferative disease; CD30 positive lymphoproliferative disorder; primary cutaneous anaplastic large cell lymphoma
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.12773

Lymphomatoid papulosis (LyP) is classified as a CD30+ primary cutaneous lymphoproliferative disease. The phenotypic variability along the spectrum of CD30+ lymphoproliferative diseases is highlighted by the distinct histologic subtypes of LyP types A, B, C, and the more recently described types D, E, and F. We report the case of an elderly woman with a clinical presentation and histopathologic findings consistent with LyP, whose atypical CD30+ infiltrate uniquely demonstrated a spindle‐cell morphology. To our knowledge, this is the first reported case of LyP characterized by CD30+ spindle‐shaped cells, and may represent a new and distinct histologic variant of LyP.