New C(4)-Functionalized Colchicine Derivatives by a Versatile Multicomponent Electrophilic Aromatic Substitution
Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H2SO4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards va...
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Published in | Helvetica chimica acta Vol. 87; no. 9; pp. 2266 - 2272 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Zürich
WILEY-VCH Verlag
01.09.2004
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H2SO4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards various tumor cell lines, and their stimulatory effect on the development of polarity in human neutrophils. |
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Bibliography: | ark:/67375/WNG-7HLGHXKB-7 ArticleID:HLCA200490203 istex:51CACDBAB0938B3C8F143296B554DF62A7306AA7 |
ISSN: | 0018-019X 1522-2675 |
DOI: | 10.1002/hlca.200490203 |