New C(4)-Functionalized Colchicine Derivatives by a Versatile Multicomponent Electrophilic Aromatic Substitution

Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H2SO4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards va...

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Bibliographic Details
Published inHelvetica chimica acta Vol. 87; no. 9; pp. 2266 - 2272
Main Authors Bensel, Nicolas, Lagnoux, David, Niggli, Verena, Wartmann, Markus, Reymond, Jean-Louis
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.09.2004
WILEY‐VCH Verlag
Wiley
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
MIGRATION
CELL-LINES
RESISTANT
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Summary:Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes and carboxylic acids or amides in H2SO4. A series of new derivatives were obtained and evaluated for their antiproliferative effect towards various tumor cell lines, and their stimulatory effect on the development of polarity in human neutrophils.
Bibliography:ark:/67375/WNG-7HLGHXKB-7
ArticleID:HLCA200490203
istex:51CACDBAB0938B3C8F143296B554DF62A7306AA7
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200490203