Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part

Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin‐type transglycosylase in...

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Published inHelvetica chimica acta Vol. 87; no. 7; pp. 1807 - 1824
Main Authors Yang, Guangbin, Mansourova, Madina, Hennig, Lothar, Findeisen, Matthias, Oehme, Ramona, Giesa, Sabine, Welzel, Peter
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.07.2004
WILEY‐VCH Verlag
Wiley
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
REAGENT
SELECTIVE DEPROTECTION
STRUCTURAL ANALOGS
2-O-ALKYL GLYCERATE PART
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Summary:Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin‐type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.
Bibliography:istex:3D40A8000C13395C4C42188C30195C606425A057
ark:/67375/WNG-9MVWFF4Q-B
ArticleID:HLCA200490161
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.200490161