Pervasive and diffuse muscle activity during REM sleep and non‐REM sleep characterises multiple system atrophy in comparison with Parkinson's disease

• Published in: Journal of sleep research Vol. 32; no. 2; pp. e13721 - n/a
• Main Authors: Silvani, Alessandro, Baldelli, Luca, Giannini, Giulia, Guaraldi, Pietro, Sambati, Luisa, Cecere, Annagrazia, Mignani, Francesco, Cortelli, Pietro, Calandra‐Buonaura, Giovanna, Provini, Federica
• Format: Journal Article
• Language: English
• Published: England 01.04.2023
• Subjects: electromyography; Electromyography - methods; Humans; Multiple System Atrophy - complications; Muscles; Parkinson Disease - complications; polysomnography; rapid‐eye‐movement sleep behaviour disorder; REM Sleep Behavior Disorder - complications; Sleep, REM - physiology; submentalis muscles; tibialis anterior muscles; wrist extensor muscles; submentalis muscles; polysomnography; tibialis anterior muscles; electromyography; wrist extensor muscles; rapid-eye-movement sleep behaviour disorder
• ISSN: 0962-1105; 1365-2869; 1365-2869
• DOI: 10.1111/jsr.13721

Summary Multiple system atrophy (MSA) and Parkinson's disease (PD) may share overlapping features particularly at early disease stage, including sleep alterations, but have profoundly different prognoses. Certain sleep phenomena and disorders of motor control are more prevalent in multiple system atrophy, such as REM sleep behaviour disorder (RBD). We quantitatively tested whether pervasive muscle activity during sleep occurs in subjects with multiple system atrophy versus Parkinson's disease. Laboratory polysomnographic studies were performed in 50 consecutive subjects with Parkinson's disease and 26 age‐ and gender‐matched subjects with multiple system atrophy at <5 years from disease onset. The distributions of normalised electromyographic activity of submentalis, wrist extensor, and tibialis anterior muscles in different wake–sleep states during the night were analysed. Subjects with multiple system atrophy had significantly higher activity of submentalis, wrist extensor, and tibialis anterior muscles than subjects with Parkinson's disease during non‐REM sleep, including separately in stages N1, N2, and N3, and during REM sleep, but not during nocturnal wakefulness. The activity of wrist extensor and tibialis anterior muscles during non‐REM sleep and the activity of tibialis anterior muscles during REM sleep were also significantly higher in subjects with multiple system atrophy and RBD than in subjects with Parkinson's disease and RBD. In conclusion, with respect to Parkinson's disease, multiple system atrophy is characterised by a pervasive and diffuse muscle overactivity that involves axial and limb muscles and occurs not only during REM sleep, but also during non‐REM sleep and between subjects with comorbid RBD.