Retrospective evaluation of toceranib phosphate (Palladia®) toxicity in cats

• Published in: Veterinary & comparative oncology Vol. 15; no. 3; pp. 710 - 717
• Main Authors: Merrick, C. H., Pierro, J., Schleis, S. E., Sones, E. A., Wright, Z. M., Regan, R. C., Siedlecki, C. T., Bergman, P. J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2017
• Subjects: Alanine Transaminase - blood; Animals; Antineoplastic Agents - therapeutic use; Antineoplastic Agents - toxicity; Azotemia - chemically induced; Azotemia - veterinary; cancer; Cat Diseases - drug therapy; Cats; feline; Female; Gastrointestinal Tract - drug effects; Indoles - therapeutic use; Indoles - toxicity; Male; Neoplasms - drug therapy; Neoplasms - veterinary; Neutropenia - chemically induced; Neutropenia - veterinary; Palladia; Pyrroles - therapeutic use; Pyrroles - toxicity; Retrospective Studies; Thrombocytopenia - chemically induced; Thrombocytopenia - veterinary; toceranib; toxicity; toceranib; toxicity; Palladia; cancer; feline
• ISSN: 1476-5810; 1476-5829
• DOI: 10.1111/vco.12211

The purpose of this study was to describe the toxicity profile of toceranib phosphate in tumour bearing cats. Medical records were reviewed from seven institutions. Patients with incomplete medical records and those receiving concurrent chemotherapy or NSAIDs (non‐steroidal anti‐inflammatory) were excluded. Fifty‐five cats met the inclusion criteria. Carcinoma was diagnosed in 55% of cases. Median oral toceranib dose was 2.7 mg kg−1 and was most commonly administered on Monday, Wednesday and Friday. Thrombocytopenia (16.3%) and neutropenia (9.1%) were the most common haematologic toxicities. Azotemia (14.5%) and alanine aminotransferase (ALT) elevations (7.2%) were the most frequently encountered biochemical alterations. Gastrointestinal (GI) toxicity was seen in 21.8% of cats, and was lower than previously reported in dogs. The results of this study showed that treatment of cats with toceranib is well‐tolerated and toxicity is uncommon. Additional studies to define a more structured dosing schedule and to evaluate the efficacy of toceranib in the treatment of feline cancers are needed.