Four‐Year Follow‐up of [18F]Fluorodeoxyglucose Positron Emission Tomography–Based Parkinson's Disease–Related Pattern Expression in 20 Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression
Background Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [18F]fluorodeoxyglucose‐positron emission tomography (PET)–based PD‐related brain pattern can be used to monit...
Saved in:
| Published in | Movement disorders Vol. 36; no. 1; pp. 230 - 235 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
01.01.2021
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0885-3185 1531-8257 |
| DOI | 10.1002/mds.28260 |
Cover
Loading…
| Abstract | Background
Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [18F]fluorodeoxyglucose‐positron emission tomography (PET)–based PD‐related brain pattern can be used to monitor disease progression.
Objective
We longitudinally investigated PD‐related brain pattern expression changes in 20 subjects with isolated rapid eye movement sleep behavior disorder to investigate whether this may be a suitable technique to study prodromal PD progression in these patients and to identify potential phenoconverters.
Methods
Subjects underwent two [18F]fluorodeoxyglucose‐PET brain scans ~3.7 years apart, along with baseline and repeated motor, cognitive, and olfactory testing within roughly the same time frame.
Results
At baseline, 8 of 20 (40%) subjects significantly expressed the PD‐related brain pattern (with z scores above the receiver operating characteristic–determined threshold). At follow‐up, six additional subjects exhibited significant PD‐related brain pattern expression (70% in total). PD‐related brain pattern expression increased in all subjects (P = 0.00008). Four subjects (20%), all with significant baseline PD‐related brain pattern expression, phenoconverted to clinical PD.
Conclusions
Suprathreshold PD‐related brain pattern expression and greater score rate of change may signify greater shorter‐term risk for phenoconversion. Our results support the use of serial PD‐related brain pattern expression measurements as a prodromal PD progression biomarker in patients with isolated rapid eye movement sleep behavior disorder. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society |
|---|---|
| AbstractList | Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha-synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [
F]fluorodeoxyglucose-positron emission tomography (PET)-based PD-related brain pattern can be used to monitor disease progression.
We longitudinally investigated PD-related brain pattern expression changes in 20 subjects with isolated rapid eye movement sleep behavior disorder to investigate whether this may be a suitable technique to study prodromal PD progression in these patients and to identify potential phenoconverters.
Subjects underwent two [
F]fluorodeoxyglucose-PET brain scans ~3.7 years apart, along with baseline and repeated motor, cognitive, and olfactory testing within roughly the same time frame.
At baseline, 8 of 20 (40%) subjects significantly expressed the PD-related brain pattern (with z scores above the receiver operating characteristic-determined threshold). At follow-up, six additional subjects exhibited significant PD-related brain pattern expression (70% in total). PD-related brain pattern expression increased in all subjects (P = 0.00008). Four subjects (20%), all with significant baseline PD-related brain pattern expression, phenoconverted to clinical PD.
Suprathreshold PD-related brain pattern expression and greater score rate of change may signify greater shorter-term risk for phenoconversion. Our results support the use of serial PD-related brain pattern expression measurements as a prodromal PD progression biomarker in patients with isolated rapid eye movement sleep behavior disorder. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Background Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [18F]fluorodeoxyglucose‐positron emission tomography (PET)–based PD‐related brain pattern can be used to monitor disease progression. Objective We longitudinally investigated PD‐related brain pattern expression changes in 20 subjects with isolated rapid eye movement sleep behavior disorder to investigate whether this may be a suitable technique to study prodromal PD progression in these patients and to identify potential phenoconverters. Methods Subjects underwent two [18F]fluorodeoxyglucose‐PET brain scans ~3.7 years apart, along with baseline and repeated motor, cognitive, and olfactory testing within roughly the same time frame. Results At baseline, 8 of 20 (40%) subjects significantly expressed the PD‐related brain pattern (with z scores above the receiver operating characteristic–determined threshold). At follow‐up, six additional subjects exhibited significant PD‐related brain pattern expression (70% in total). PD‐related brain pattern expression increased in all subjects (P = 0.00008). Four subjects (20%), all with significant baseline PD‐related brain pattern expression, phenoconverted to clinical PD. Conclusions Suprathreshold PD‐related brain pattern expression and greater score rate of change may signify greater shorter‐term risk for phenoconversion. Our results support the use of serial PD‐related brain pattern expression measurements as a prodromal PD progression biomarker in patients with isolated rapid eye movement sleep behavior disorder. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society BackgroundIsolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [18F]fluorodeoxyglucose‐positron emission tomography (PET)–based PD‐related brain pattern can be used to monitor disease progression.ObjectiveWe longitudinally investigated PD‐related brain pattern expression changes in 20 subjects with isolated rapid eye movement sleep behavior disorder to investigate whether this may be a suitable technique to study prodromal PD progression in these patients and to identify potential phenoconverters.MethodsSubjects underwent two [18F]fluorodeoxyglucose‐PET brain scans ~3.7 years apart, along with baseline and repeated motor, cognitive, and olfactory testing within roughly the same time frame.ResultsAt baseline, 8 of 20 (40%) subjects significantly expressed the PD‐related brain pattern (with z scores above the receiver operating characteristic–determined threshold). At follow‐up, six additional subjects exhibited significant PD‐related brain pattern expression (70% in total). PD‐related brain pattern expression increased in all subjects (P = 0.00008). Four subjects (20%), all with significant baseline PD‐related brain pattern expression, phenoconverted to clinical PD.ConclusionsSuprathreshold PD‐related brain pattern expression and greater score rate of change may signify greater shorter‐term risk for phenoconversion. Our results support the use of serial PD‐related brain pattern expression measurements as a prodromal PD progression biomarker in patients with isolated rapid eye movement sleep behavior disorder. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society |
| Author | García, David Vállez Janzen, Annette Peretti, Débora E. Reesink, Fransje E. Oertel, Wolfgang H. Kogan, Rosalie V. Reetz, Kathrin Booij, Jan Kok, Jelmer G. Gurvits, Vita Teune, Laura K. Overeem, Sebastiaan Mayer, Geert Pijpers, Angelique Renken, Remco J. Meles, Sanne K. Sittig, Elisabeth Leenders, Klaus L. Bernhard, Felix |
| AuthorAffiliation | 2 Department of Neurology Philipps‐Universität Marburg Marburg Germany 3 Department of Neurology University of Groningen, University Medical Center Groningen Groningen the Netherlands 4 Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center University of Groningen Groningen the Netherlands 5 Institute for Neurogenomics Helmholtz Center for Health and Environment Munich Germany 1 Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen Groningen the Netherlands |
| AuthorAffiliation_xml | – name: 5 Institute for Neurogenomics Helmholtz Center for Health and Environment Munich Germany – name: 1 Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen Groningen the Netherlands – name: 3 Department of Neurology University of Groningen, University Medical Center Groningen Groningen the Netherlands – name: 2 Department of Neurology Philipps‐Universität Marburg Marburg Germany – name: 4 Department of Biomedical Sciences of Cells & Systems, Cognitive Neuroscience Center University of Groningen Groningen the Netherlands |
| Author_xml | – sequence: 1 givenname: Rosalie V. orcidid: 0000-0003-3077-4181 surname: Kogan fullname: Kogan, Rosalie V. email: r.v.kogan@umcg.nl organization: University of Groningen, University Medical Center Groningen – sequence: 2 givenname: Annette surname: Janzen fullname: Janzen, Annette organization: Philipps‐Universität Marburg – sequence: 3 givenname: Sanne K. surname: Meles fullname: Meles, Sanne K. organization: University of Groningen, University Medical Center Groningen – sequence: 4 givenname: Elisabeth surname: Sittig fullname: Sittig, Elisabeth organization: Philipps‐Universität Marburg – sequence: 5 givenname: Remco J. surname: Renken fullname: Renken, Remco J. organization: University of Groningen – sequence: 6 givenname: Vita surname: Gurvits fullname: Gurvits, Vita organization: University of Groningen, University Medical Center Groningen – sequence: 7 givenname: Geert surname: Mayer fullname: Mayer, Geert organization: Philipps‐Universität Marburg – sequence: 8 givenname: Klaus L. surname: Leenders fullname: Leenders, Klaus L. organization: University of Groningen, University Medical Center Groningen – sequence: 9 givenname: Wolfgang H. surname: Oertel fullname: Oertel, Wolfgang H. organization: Helmholtz Center for Health and Environment – sequence: 11 givenname: Jan surname: Booij fullname: Booij, Jan – sequence: 12 givenname: Kathrin surname: Reetz fullname: Reetz, Kathrin – sequence: 13 givenname: Sebastiaan surname: Overeem fullname: Overeem, Sebastiaan – sequence: 14 givenname: Angelique surname: Pijpers fullname: Pijpers, Angelique – sequence: 15 givenname: Felix surname: Bernhard fullname: Bernhard, Felix – sequence: 16 givenname: David Vállez surname: García fullname: García, David Vállez – sequence: 17 givenname: Débora E. surname: Peretti fullname: Peretti, Débora E. – sequence: 18 givenname: Laura K. surname: Teune fullname: Teune, Laura K. – sequence: 19 givenname: Fransje E. surname: Reesink fullname: Reesink, Fransje E. – sequence: 20 givenname: Jelmer G. surname: Kok fullname: Kok, Jelmer G. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32909650$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks1u1DAQxyNURD_gwAsgSxwQh239lcS5IPVjFyq1YtUtB4SQ5SaTXZckE-xkt3vrIyDxhj3zEHi7WwQITh77_5_fjDyzG2012EAUPWd0n1HKD-rC73PFE_oo2mGxYAPF43Qr2qFKxQPBVLwd7Xp_TSljMUueRNuCZzRLYroT_Rhh7-5uv30E48gIqwoX4da3BEvyianR51HVo8MC8GY5rfocPZAxets5bMiwtt7bEFxijVNn2tny7vb7kfFQkLFxX2zjsXnlyYn1EB6DdgGV6e7VrgMXCDetgzXDNoTTlWCh6TxZ2G5GTj2u_RemtQUZLoGc4xzq4CCTCqAlRzAzc4tuVQNdAY5MZrjwZBx6dlibahVNNzWeRo9LU3l4tjn3og-j4eXxu8HZ-7enx4dng1zwmA7SVCqTZ5RT4KbM80JRnmXxVQ4yl1zIhMdCcioTIVQJMkm5gZRnwHkChSyl2IverLltf1VDkYd2nal062xt3FKjsfpPpbEzPcW5TlXGhGQB8HIDcPi1B9_p6zCmJvSsuVRUiCQMMLhe_F7mF_9husFwsDbkDr13UOrcduGDcVXVVppRvdofHfZH3-9PyHj9V8YD9F_eDX1hK1j-36jPTybrjJ-sEt40 |
| CitedBy_id | crossref_primary_10_3233_JPD_212571 crossref_primary_10_1093_brain_awad072 crossref_primary_10_1038_s41467_024_51502_7 crossref_primary_10_3233_JPD_230385 crossref_primary_10_3390_brainsci12020199 crossref_primary_10_1007_s00702_024_02846_3 crossref_primary_10_1038_s41531_024_00813_z crossref_primary_10_1212_WNL_0000000000012228 crossref_primary_10_1016_j_cmpb_2022_107042 crossref_primary_10_1212_WNL_0000000000210105 crossref_primary_10_3390_brainsci12091146 crossref_primary_10_1002_mds_28859 crossref_primary_10_1007_s10072_023_06829_2 crossref_primary_10_1111_jsr_14263 crossref_primary_10_1186_s10020_021_00327_x crossref_primary_10_1007_s11910_022_01171_0 crossref_primary_10_2174_1570159X21666230801140648 crossref_primary_10_1212_WNL_0000000000208015 crossref_primary_10_3233_JPD_223201 crossref_primary_10_1002_ana_25962 crossref_primary_10_1007_s13311_023_01433_w crossref_primary_10_1002_jnr_25099 crossref_primary_10_1002_mds_28592 crossref_primary_10_1016_S1474_4422_21_00176_9 crossref_primary_10_1038_s41531_024_00685_3 crossref_primary_10_1016_j_parkreldis_2020_10_036 crossref_primary_10_1007_s11065_022_09572_1 crossref_primary_10_1111_ejn_16296 crossref_primary_10_3389_fneur_2022_1009907 crossref_primary_10_1002_ana_26085 crossref_primary_10_1111_bcpt_14042 crossref_primary_10_1002_mds_29177 crossref_primary_10_1002_mds_29138 crossref_primary_10_1038_s41582_022_00753_3 crossref_primary_10_1002_mds_29236 crossref_primary_10_1007_s00259_023_06289_y crossref_primary_10_1016_j_parkreldis_2024_107042 |
| Cites_doi | 10.1007/s00259-019-04497-z 10.1002/mds.25361 10.1002/mds.23079 10.1002/mds.26637 10.1093/brain/awz030 10.1007/s00259-016-3312-x 10.1212/WNL.0000000000004058 10.1016/j.sleep.2012.10.009 10.1371/journal.pone.0089741 10.1016/S1474-4422(11)70152-1 10.1007/s12021-014-9235-4 10.1016/S1474-4422(10)70002-8 10.1136/jnnp.51.6.745 10.1523/JNEUROSCI.4188-09.2010 10.1002/mds.27094 10.1016/j.tins.2009.06.003 10.1093/brain/awm086 10.1080/13854046.2015.1087596 10.1016/j.parkreldis.2013.02.009 10.1002/mds.22340 10.1212/WNL.0000000000000130 10.1002/mds.10473 10.1002/ana.25026 |
| ContentType | Journal Article |
| Contributor | Reesink, Fransje E Overeem, Sebastiaan García, David Vállez Peretti, Débora E Pijpers, Angelique Reetz, Kathrin Booij, Jan Bernhard, Felix Teune, Laura K Kok, Jelmer G |
| Contributor_xml | – sequence: 1 givenname: Jan surname: Booij fullname: Booij, Jan – sequence: 2 givenname: Kathrin surname: Reetz fullname: Reetz, Kathrin – sequence: 3 givenname: Sebastiaan surname: Overeem fullname: Overeem, Sebastiaan – sequence: 4 givenname: Angelique surname: Pijpers fullname: Pijpers, Angelique – sequence: 5 givenname: Felix surname: Bernhard fullname: Bernhard, Felix – sequence: 6 givenname: David Vállez surname: García fullname: García, David Vállez – sequence: 7 givenname: Débora E surname: Peretti fullname: Peretti, Débora E – sequence: 8 givenname: Laura K surname: Teune fullname: Teune, Laura K – sequence: 9 givenname: Fransje E surname: Reesink fullname: Reesink, Fransje E – sequence: 10 givenname: Jelmer G surname: Kok fullname: Kok, Jelmer G |
| Copyright | 2020 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2020 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society – notice: 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. – notice: 2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| CorporateAuthor | and the REMPET Working Group REMPET Working Group |
| CorporateAuthor_xml | – name: and the REMPET Working Group – name: REMPET Working Group |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK 8FD FR3 K9. NAPCQ P64 RC3 5PM |
| DOI | 10.1002/mds.28260 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Genetics Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nursing & Allied Health Premium Genetics Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts |
| DatabaseTitleList | MEDLINE Nursing & Allied Health Premium |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | FDG‐PET PDRP Expression Progression in iRBD |
| EISSN | 1531-8257 |
| EndPage | 235 |
| ExternalDocumentID | PMC7891341 32909650 10_1002_mds_28260 MDS28260 |
| Genre | shortCommunication Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Stichting ParkinsonFonds – fundername: ParkinsonFonds Deutschland – fundername: ; |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 123 1CY 1L6 1OB 1OC 1ZS 24P 31~ 33P 3PY 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5VS 66C 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AIACR AIDQK AIDYY AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC FYBCS G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6M MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ SV3 TEORI TWZ UB1 V2E V9Y W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WVDHM WXI WXSBR XG1 XV2 ZGI ZZTAW ~IA ~WT AAHHS AAYXX ACCFJ AEEZP AEQDE AIWBW AJBDE CITATION CGR CUY CVF ECM EIF NPM 7TK 8FD FR3 K9. NAPCQ P64 RC3 5PM |
| ID | FETCH-LOGICAL-c3250-7748ac9020e2afccd802995bce4c4234625342046338fe4672ae729e226ed4f43 |
| IEDL.DBID | 24P |
| ISSN | 0885-3185 |
| IngestDate | Thu Aug 21 14:14:50 EDT 2025 Fri Jul 25 23:05:52 EDT 2025 Mon Jul 21 05:56:41 EDT 2025 Tue Jul 01 01:44:26 EDT 2025 Thu Apr 24 22:55:45 EDT 2025 Wed Aug 20 07:26:51 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Parkinson's disease-related pattern [18F]FDG-PET prodromal progression biomarker neuroimaging rapid eye movement sleep behavior disorder |
| Language | English |
| License | Attribution 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3250-7748ac9020e2afccd802995bce4c4234625342046338fe4672ae729e226ed4f43 |
| Notes | Full financial disclosures and author roles may be found in the online version of this article. Members of the REMPET Working Group are listed in the Appendix. Rosalie V. Kogan, Annette Janzen, Klaus L. Leenders, and Wolfgang H. Oertel share first and last authorship. Nothing to report. This study was funded by Dutch “Stichting ParkinsonFonds” and the German “ParkinsonFonds Deutschland. The funders of this study did not have any role in designing this study, collecting, analyzing, or interpreting the data, or in writing this article. The corresponding author had access to and responsibility for all of the relevant data that were submitted for publication. Relevant conflicts of interest/financial disclosures Funding agencies ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 Funding agencies: This study was funded by Dutch “Stichting ParkinsonFonds” and the German “ParkinsonFonds Deutschland. The funders of this study did not have any role in designing this study, collecting, analyzing, or interpreting the data, or in writing this article. The corresponding author had access to and responsibility for all of the relevant data that were submitted for publication. Relevant conflicts of interest/financial disclosures: Nothing to report. |
| ORCID | 0000-0003-3077-4181 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.28260 |
| PMID | 32909650 |
| PQID | 2480336290 |
| PQPubID | 1016421 |
| PageCount | 36 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7891341 proquest_journals_2480336290 pubmed_primary_32909650 crossref_citationtrail_10_1002_mds_28260 crossref_primary_10_1002_mds_28260 wiley_primary_10_1002_mds_28260_MDS28260 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | January 2021 |
| PublicationDateYYYYMMDD | 2021-01-01 |
| PublicationDate_xml | – month: 01 year: 2021 text: January 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | Hoboken, USA |
| PublicationPlace_xml | – name: Hoboken, USA – name: United States – name: Hoboken |
| PublicationTitle | Movement disorders |
| PublicationTitleAlternate | Mov Disord |
| PublicationYear | 2021 |
| Publisher | John Wiley & Sons, Inc Wiley Subscription Services, Inc |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: Wiley Subscription Services, Inc |
| References | 2013; 28 2017; 82 2017; 89 2016; 31 2011; 10 1988; 51 2003; 18 2014; 82 2019; 142 2010; 67 2013; 19 2013; 14 2009; 32 2010; 25 2015; 29 2013; 76 2017; 32 2007; 130 2016; 43 2008; 23 2020; 47 2014; 9 2010; 30 2014; 12 2010; 9 e_1_2_9_11_1 Spetsieris P (e_1_2_9_5_1) 2013; 76 e_1_2_9_10_1 e_1_2_9_13_1 e_1_2_9_12_1 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_17_1 e_1_2_9_16_1 e_1_2_9_19_1 e_1_2_9_18_1 Shulman LM (e_1_2_9_20_1) 2010; 67 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 |
| References_xml | – volume: 14 start-page: 744 issue: 8 year: 2013 end-page: 748 article-title: Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16‐year update on a previously reported series publication-title: Sleep Med – volume: 9 start-page: 149 issue: 2 year: 2010 end-page: 158 article-title: Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis publication-title: Lancet Neurol – volume: 142 start-page: 744 issue: 3 year: 2019 end-page: 759 article-title: Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study publication-title: Brain – volume: 67 start-page: 64 issue: 1 year: 2010 end-page: 70 article-title: The clinically important difference on the Unified Parkinson's Disease Rating ScaleCIDs on the UPDRS publication-title: NEUR – volume: 47 start-page: 425 issue: 2 year: 2020 end-page: 436 article-title: Functional impact of subthalamotomy by magnetic resonance‐guided focused ultrasound in Parkinson's disease: a hybrid PET/MR study of resting‐state brain metabolism publication-title: Eur J Nucl Med Mol Imaging – volume: 82 start-page: 620 issue: 7 year: 2014 end-page: 627 article-title: Abnormal metabolic network activity in REM sleep behavior disorder publication-title: Neurology – volume: 9 issue: 2 year: 2014 article-title: Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients publication-title: PLoS One – volume: 32 start-page: 548 issue: 10 year: 2009 end-page: 557 article-title: Metabolic brain networks in neurodegenerative disorders: a functional imaging approach publication-title: Trends Neurosci – volume: 32 start-page: 1482 issue: 10 year: 2017 end-page: 1486 article-title: FDG PET, dopamine transporter SPECT, and olfaction: combining biomarkers in REM sleep behavior disorder publication-title: Mov Disord – volume: 82 start-page: 419 issue: 3 year: 2017 end-page: 428 article-title: Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder publication-title: Ann Neurol – volume: 76 year: 2013 article-title: Identification of disease‐related spatial covariance patterns using neuroimaging data publication-title: J Vis Exp – volume: 89 start-page: 88 issue: 1 year: 2017 end-page: 100 article-title: Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium publication-title: Neurology – volume: 18 start-page: 738 issue: 7 year: 2003 end-page: 750 article-title: The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations publication-title: Mov Disord – volume: 10 start-page: 797 issue: 9 year: 2011 end-page: 805 article-title: Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid‐eye‐movement sleep behaviour disorder: a prospective study publication-title: Lancet Neurol – volume: 23 start-page: 2129 issue: 15 year: 2008 end-page: 2170 article-title: Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): scale presentation and clinimetric testing results publication-title: Mov Disord – volume: 25 start-page: 936 issue: 7 year: 2010 end-page: 940 article-title: The Montreal Cognitive Assessment: a screening tool for mild cognitive impairment in REM sleep behavior disorder publication-title: Mov Disord – volume: 43 start-page: 1060 issue: 6 year: 2016 end-page: 1066 article-title: [(123)]FP‐CIT SPECT scans initially rated as normal became abnormal over time in patients with probable dementia with Lewy bodies publication-title: Eur J Nucl Med Mol Imaging – volume: 30 start-page: 1049 issue: 3 year: 2010 end-page: 1056 article-title: Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease publication-title: J Neurosci – volume: 31 start-page: 1408 issue: 9 year: 2016 end-page: 1413 article-title: Optimizing odor identification testing as quick and accurate diagnostic tool for Parkinson's disease publication-title: Mov Disord – volume: 12 start-page: 575 issue: 4 year: 2014 end-page: 593 article-title: A standardized [18F]‐FDG‐PET template for spatial normalization in statistical parametric mapping of dementia publication-title: Neuroinformatics – volume: 29 start-page: 824 issue: 6 year: 2015 end-page: 835 article-title: Longitudinal change in performance on the Montreal Cognitive Assessment in older adults publication-title: Clin Neuropsychol – volume: 130 start-page: 1834 issue: pt 7 year: 2007 end-page: 1846 article-title: Changes in network activity with the progression of Parkinson's disease publication-title: Brain – volume: 19 start-page: 600 issue: 6 year: 2013 end-page: 604 article-title: Longitudinal assessment of olfactory function in idiopathic REM sleep behavior disorder publication-title: Parkinsonism Relat Disord – volume: 51 start-page: 745 issue: 6 year: 1988 end-page: 752 article-title: The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease publication-title: J Neurol Neurosurg Psychiatry – volume: 28 start-page: 547 issue: 4 year: 2013 end-page: 551 article-title: Validation of parkinsonian disease‐related metabolic brain patterns publication-title: Mov Disord – ident: e_1_2_9_12_1 doi: 10.1007/s00259-019-04497-z – ident: e_1_2_9_7_1 doi: 10.1002/mds.25361 – ident: e_1_2_9_18_1 doi: 10.1002/mds.23079 – ident: e_1_2_9_19_1 doi: 10.1002/mds.26637 – ident: e_1_2_9_3_1 doi: 10.1093/brain/awz030 – ident: e_1_2_9_26_1 doi: 10.1007/s00259-016-3312-x – ident: e_1_2_9_14_1 doi: 10.1212/WNL.0000000000004058 – ident: e_1_2_9_2_1 doi: 10.1016/j.sleep.2012.10.009 – ident: e_1_2_9_4_1 doi: 10.1371/journal.pone.0089741 – ident: e_1_2_9_24_1 doi: 10.1016/S1474-4422(11)70152-1 – ident: e_1_2_9_15_1 doi: 10.1007/s12021-014-9235-4 – volume: 67 start-page: 64 issue: 1 year: 2010 ident: e_1_2_9_20_1 article-title: The clinically important difference on the Unified Parkinson's Disease Rating ScaleCIDs on the UPDRS publication-title: NEUR – ident: e_1_2_9_23_1 doi: 10.1016/S1474-4422(10)70002-8 – ident: e_1_2_9_13_1 doi: 10.1136/jnnp.51.6.745 – ident: e_1_2_9_9_1 doi: 10.1523/JNEUROSCI.4188-09.2010 – ident: e_1_2_9_8_1 doi: 10.1002/mds.27094 – ident: e_1_2_9_6_1 doi: 10.1016/j.tins.2009.06.003 – ident: e_1_2_9_11_1 doi: 10.1093/brain/awm086 – ident: e_1_2_9_21_1 doi: 10.1080/13854046.2015.1087596 – ident: e_1_2_9_22_1 doi: 10.1016/j.parkreldis.2013.02.009 – ident: e_1_2_9_17_1 doi: 10.1002/mds.22340 – ident: e_1_2_9_10_1 doi: 10.1212/WNL.0000000000000130 – ident: e_1_2_9_16_1 doi: 10.1002/mds.10473 – ident: e_1_2_9_25_1 doi: 10.1002/ana.25026 – volume: 76 start-page: e50319 year: 2013 ident: e_1_2_9_5_1 article-title: Identification of disease‐related spatial covariance patterns using neuroimaging data publication-title: J Vis Exp |
| SSID | ssj0011516 |
| Score | 2.506905 |
| Snippet | Background
Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and... Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha-synucleinopathies, such as Parkinson's disease (PD) and dementia with... BackgroundIsolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and... |
| SourceID | pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 230 |
| SubjectTerms | [18F]FDG‐PET Behavior disorders Brief Report Cognitive ability Dementia disorders Eye movements Follow-Up Studies Humans Lewy bodies Movement disorders Neurodegenerative diseases Neuroimaging Parkinson Disease - diagnostic imaging Parkinson's disease Parkinson's disease–related pattern Positron emission tomography prodromal progression biomarker Prodromal Symptoms rapid eye movement sleep behavior disorder Regular Issue REM sleep REM Sleep Behavior Disorder - diagnostic imaging Sleep Sleep disorders |
| Title | Four‐Year Follow‐up of [18F]Fluorodeoxyglucose Positron Emission Tomography–Based Parkinson's Disease–Related Pattern Expression in 20 Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.28260 https://www.ncbi.nlm.nih.gov/pubmed/32909650 https://www.proquest.com/docview/2480336290 https://pubmed.ncbi.nlm.nih.gov/PMC7891341 |
| Volume | 36 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bi9NAFB6WFcQX8W51lYMI-lK3nUyaBJ_UNqxCpWx3YUUkZCYzbKFNStOyu2_7EwT_4T77I_xmctGyCr6EpufkMpwzc77MnPMNYy9DKSOlpN-NAhyEMUE3lX3dlUDrKRA2T5XLtvg8ODgWn078kx32tqmFqfgh2gk32zPceG07eCrL_d-koYusfIPvhQG-12_Y0lq7fQEXk3YJAaFsUEFI35UIN7RCPb7fXrodjK4hzOuJkn8CWBeB4jvsdg0d6V1l67tsR-f32M1xvTh-n_2MoXF1-f0LnJdi2Lc4w9lmSYWhr_0w_hbPNwXGS12cX9SZ6jSxOVurIqcR7G0nzuioWNQs1leXP94jxmVkK6NdkdirkobVgg5kLo3OSW1BEO5wXufU5jTLifeswBZblmTneukjnNzpH6bLWUajC03jwpGVr2k613pJNVXjihpGUJqeFmclTfDOq2KBpk9sMln1jAfsOB4dfTjo1ps5dJUHmAUUL8JURUCnmqdGqSzsIRL6UmmhAOlgP98T3PKXeaHRGL55qgH8NeChzoQR3kO2mxe5fszQgr6Ugc-NQWw1JpQq4zwwKR9kGY941mGvG6smqmY6txtuzJOKo5kncIDEOUCHvWhVlxW9x9-U9hrXSOoeDokIex6ifwTxo8pL2jt4-DcC9O2wYMt_WgXL6b0tyWenjts7sMvGoo8mOE_790sl4-HU_Xjy_6pP2S1uU3LcDNIe212vNvoZMNVaPnd9B8fhIf8F51ooEg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9NAEF-OE9QX8dvqqYMI-hKv3WyaBHxRr6Gn16PYHpyIhOwXV2izpR_c3dv9CYL_4T37Rzi72UTLKfhS0s4kzTKzO7_MzvxCyMuE81QIHgVpjB9M6zgoeEcFHNF6gQibFsJVWxx2-0fs43F0vEXe1r0wFT9Ek3CzM8Ot13aC24T07m_W0JlcvsEHhi4-sF9jiMutT1M2bPYQMJZ1KwwZuR7hmleoTXebUzej0RWIebVS8k8E60JQdpvc8tgR3lXGvkO2VHmXXB_43fF75GeGGpcX37-g90KGBjan-G09B6PhayfJvmXTtcEFU5mzc1-qDkNbtLUwJfTQ4DZzBmMz8zTWlxc_3mOQk2Bbo12X2Ksl7FU7OihzdXROajuC8Apnvqi2hEkJtG0FtttyCTbZC_vo5U7_czGfSOidKxgYx1a-gtFUqTl4rsYF1JSgMDoxp0sY4j0vzAyHPrTVZNV_3CdHWW_8oR_4tzkEIkSchTCeJYVIEZ4qWmghZNLGUBhxoZhATIcWjEJGLYFZmGiF6zctFCJ_hfhQSaZZ-IBsl6ZUjwiOoMN5HFGtMbhqnXAhKY11QbtS0pTKFnldWzUXnurcvnFjmlckzTRHB8idA7TIi0Z1XvF7_E1pp3aN3E9xlLCkHWL4T1H8sPKS5goh_poi9m2ReMN_GgVL6r0pKScnjtw7tvvGrINDcJ7275vKB3sjd_D4_1Wfkxv98eAgP9g__PSE3KS2Pselk3bI9mqxVk8RYK34MzePfgHpWCqe |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEF5VrVRxQZRnSoERQoKLabJex7Y4AYnVAqks0kpFCFnelxop8Vp5qO2tPwGJf9gzP4LZ9QOigsQlSjyTtVc7u_PtzsxnQl5EnMdC8MCLQ_xgWodeznvK44jWc0TYNBcu2-Kof3DCPpwGpxvkTVMLU_FDtAdudma49dpO8FLq_d-koTO5eI37hT7u17dssM_m81GWtiEEdGX9CkIGrkS4oRXq0v32r-vO6AbCvJko-SeAdR4ouUNu19AR3lZjvUM2VHGXbI_q4Pg98jNBjeur71_QeCHB8TXn-GtVgtHwtRcl35LpyuB6qczFZZ2pDqnN2ZqbAoY43vbgDI7NrGaxvr768Q59nARbGe2KxF4uYFAFdFDm0uic1BYEYQsXdU5tAZMCaNcKbLHlAuxZLxyikTv9z3k5kTC8VDAyjqx8CeOpUiXUVI1zaBhBYXxmzheQ4jPPzQy7ntpksuoe98lJMjx-f-DVL3PwhI8wC1E8i3IRIzpVNNdCyKiLnjDgQjGBkI7hPsxn1PKX-ZFWuHzTXCHwVwgPlWSa-Q_IZmEK9YhgD3qchwHVGn2r1hEXktJQ57QvJY2p7JBXzahmomY6ty_cmGYVRzPN0AAyZwAd8rxVLSt6j78p7TWmkdUzHCUs6vro_WMUP6yspG3Bx6sxQt8OCdfsp1WwnN7rkmJy5ri9Qxs2Zj3sgrO0fz9UNhqM3Zfd_1d9RrbTQZJ9Ojz6-JjcojY7xx0m7ZHN5XylniC8WvKnbhr9AvjUKcc |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Four%E2%80%90Year+Follow%E2%80%90up+of+%5B18F%5DFluorodeoxyglucose+Positron+Emission+Tomography%E2%80%93Based+Parkinson%27s+Disease%E2%80%93Related+Pattern+Expression+in+20+Patients+with+Isolated+Rapid+Eye+Movement+Sleep+Behavior+Disorder+Shows+Prodromal+Progression&rft.jtitle=Movement+disorders&rft.au=Kogan%2C+Rosalie+V.&rft.au=Janzen%2C+Annette&rft.au=Meles%2C+Sanne+K.&rft.au=Sittig%2C+Elisabeth&rft.date=2021-01-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=0885-3185&rft.eissn=1531-8257&rft.volume=36&rft.issue=1&rft.spage=230&rft.epage=235&rft_id=info:doi/10.1002%2Fmds.28260&rft.externalDBID=10.1002%252Fmds.28260&rft.externalDocID=MDS28260 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0885-3185&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0885-3185&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0885-3185&client=summon |