Four‐Year Follow‐up of [18F]Fluorodeoxyglucose Positron Emission Tomography–Based Parkinson's Disease–Related Pattern Expression in 20 Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression

• Published in: Movement disorders Vol. 36; no. 1; pp. 230 - 235
• Main Authors: Kogan, Rosalie V., Janzen, Annette, Meles, Sanne K., Sittig, Elisabeth, Renken, Remco J., Gurvits, Vita, Mayer, Geert, Leenders, Klaus L., Oertel, Wolfgang H., Booij, Jan, Reetz, Kathrin, Overeem, Sebastiaan, Pijpers, Angelique, Bernhard, Felix, García, David Vállez, Peretti, Débora E., Teune, Laura K., Reesink, Fransje E., Kok, Jelmer G.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2021; Wiley Subscription Services, Inc
• Subjects: [18F]FDG‐PET; Behavior disorders; Brief Report; Cognitive ability; Dementia disorders; Eye movements; Follow-Up Studies; Humans; Lewy bodies; Movement disorders; Neurodegenerative diseases; Neuroimaging; Parkinson Disease - diagnostic imaging; Parkinson's disease; Parkinson's disease–related pattern; Positron emission tomography; prodromal progression biomarker; Prodromal Symptoms; rapid eye movement sleep behavior disorder; Regular Issue; REM sleep; REM Sleep Behavior Disorder - diagnostic imaging; Sleep; Sleep disorders; Parkinson's disease-related pattern; [18F]FDG-PET; prodromal progression biomarker; neuroimaging; rapid eye movement sleep behavior disorder
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.28260

Background Isolated rapid eye movement sleep behavior disorder is known to be prodromal for alpha‐synucleinopathies, such as Parkinson's disease (PD) and dementia with Lewy bodies. The [18F]fluorodeoxyglucose‐positron emission tomography (PET)–based PD‐related brain pattern can be used to monitor disease progression. Objective We longitudinally investigated PD‐related brain pattern expression changes in 20 subjects with isolated rapid eye movement sleep behavior disorder to investigate whether this may be a suitable technique to study prodromal PD progression in these patients and to identify potential phenoconverters. Methods Subjects underwent two [18F]fluorodeoxyglucose‐PET brain scans ~3.7 years apart, along with baseline and repeated motor, cognitive, and olfactory testing within roughly the same time frame. Results At baseline, 8 of 20 (40%) subjects significantly expressed the PD‐related brain pattern (with z scores above the receiver operating characteristic–determined threshold). At follow‐up, six additional subjects exhibited significant PD‐related brain pattern expression (70% in total). PD‐related brain pattern expression increased in all subjects (P = 0.00008). Four subjects (20%), all with significant baseline PD‐related brain pattern expression, phenoconverted to clinical PD. Conclusions Suprathreshold PD‐related brain pattern expression and greater score rate of change may signify greater shorter‐term risk for phenoconversion. Our results support the use of serial PD‐related brain pattern expression measurements as a prodromal PD progression biomarker in patients with isolated rapid eye movement sleep behavior disorder. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society