A Pharmacodynamic Comparison Study of Different Botulinum Toxin Type A Preparations

• Published in: Dermatologic surgery Vol. 39; no. 1pt2; pp. 150 - 154
• Main Authors: Kim, Sung‐Beom, Ban, Bhupal, Jung, Keun‐Suk, Yang, Gi‐Hyeok
• Format: Journal Article
• Language: English
• Published: United States 01.01.2013
• Subjects: Analysis of Variance; Animals; Botulinum Toxins, Type A - pharmacology; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Muscle Weakness - chemically induced; Muscle, Skeletal - drug effects; Neurotoxins - pharmacology
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1111/dsu.12070

Background Because more botulinum toxin (BoNT) preparations have become available worldwide, there is a clinical need to compare the pharmacologic profiles of these products. Objective We compared three different preparations: onabotulinumtoxinA (ona‐BoNT/A), abobotulinumtoxinA (abo‐BoNT/A), and Neuronox (neu‐BoNT/A), in a mouse model using a digit abduction scoring (DAS) assay. Methods The efficacy, duration of effect, and safety margin of each preparation was determined after delivering a single injection to the right gastrocnemius (0–240 U/kg body weight of neu‐BoNT/A or ona‐BoNT/A; 0–600 Speywood Units/kg body weight of abo‐BoNT/A). Results Neu‐BoNT/A (intramuscular (IM) median effective dose (ED50) 11.2 ± 2.7 U/kg) and ona‐BoNT/A (IM ED50 11.9 ± 2.4 U/kg) had similar effects in terms of muscle weakness at significantly lower doses than abo‐BoNT/A (IM ED50 41.2 ± 2.4 U/kg; p < .001). The safety margin (ratio between IM ED50 and IM median lethal dose (LD50)) of neu‐BoNT/A (10.7 ± 2.6 U/kg) was also similar to that of ona‐BoNT/A (10.3 ± 1.3 U/kg) but significantly higher than that of abo‐BoNT/A (5.9 ± 0.4 U/kg; p < .02). Neu‐BoNT/A and ona‐BoNT/A also produced comparable patterns of DAS response and body weight recovery by day 29. Conclusion Neu‐BoNT/A and ona‐BoNT/A may be interchangeable based on a simple dose ratio.