Alkylation of alpha-halo diketones via enol phosphate intermediate

beta-Substituted alpha,beta-unsaturated carbonyl compounds were obtained in moderate to high yields by a 1,4-addition of organocuprates to enol phosphate intermediates formed in situ from triethyl phosphite and 2-bromo-1,3-dicarbonyl compounds.

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Bibliographic Details
Published inChemistry letters Vol. 32; no. 11; pp. 994 - 995
Main Authors Onishi, JY, Takuwa, T, Mukaiyama, T
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 05.11.2003
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
KETONES
CARBONYL-COMPOUNDS
OLEFINS
STEREOSELECTIVE SYNTHESIS
ESTERS
BETA
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Summary:beta-Substituted alpha,beta-unsaturated carbonyl compounds were obtained in moderate to high yields by a 1,4-addition of organocuprates to enol phosphate intermediates formed in situ from triethyl phosphite and 2-bromo-1,3-dicarbonyl compounds.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2003.994