Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus

is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of led to the isolation of 4 new (1:  - 4: ) and 10 known meroterpenoids (5:  - 14: ). The structures of new compounds were...

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Published inPlanta medica Vol. 86; no. 8; p. 571
Main Authors Chen, Baosong, Han, Junjie, Bao, Li, Wang, Wenzhao, Ma, Ke, Liu, Hongwei
Format Journal Article
LanguageEnglish
Published Germany 01.05.2020
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Summary:is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of led to the isolation of 4 new (1:  - 4: ) and 10 known meroterpenoids (5:  - 14: ). The structures of new compounds were determined via analysis of NMR and MS data in combination with chemical derivatization. The inhibitory activities of 1:  - 14: against -glucosidase were evaluated using -nitrophenyl- -D-glucopyranoside, sucrose, or maltose as substrate. Compounds 6, 9, 11:  - 13: were demonstrated to show the -glucosidase inhibitory activities. This work confirms the potential of in the treatment of diabetes.
ISSN:1439-0221
DOI:10.1055/a-1146-8369