The correlation of uric acid levels with biochemical parameters and dietary factors in individuals with asymptomatic hyperuricemia and gouty arthritis

• Published in: Nucleosides, nucleotides & nucleic acids Vol. 41; no. 5-6; pp. 444 - 462
• Main Authors: Türker, Perim Fatma, Hoca, Mustafa, Özduran, Gülşen, Akçil Ok, Mehtap, Demir Çelebi, Merve
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 07.07.2022; Taylor & Francis Ltd
• Subjects: Arthritis; Ascorbic acid; Asymptomatic; Biochemical parameters; C-reactive protein; Cardiovascular diseases; Diabetes mellitus; dietary factors; Gout; Hyperuricemia; Insulin; Insulin resistance; Micronutrients; Rheumatism; Serum levels; Uric acid; Vitamin B12; hyperuricemia; Biochemical parameters; dietary factors; uric acid; gout
• ISSN: 1525-7770; 1532-2335
• DOI: 10.1080/15257770.2022.2051047

Diet may play an important role in the development of asymptomatic hyperuricemia (ASH) and gouty arthritis (GOUT). However, the association between dietary factors and hyperuricemia remains unclear. Serum uric acid levels are affected by dietary factors. This study aimed to evaluate the correlation of uric acid levels with biochemical parameters and dietary factors in individuals with ASH and GOUT. This study was conducted in 145 individuals with ASH and GOUT. General characteristics of individuals were collected via face-to-face interviews. Food frequency questionnaire was used to obtain energy, macro- and micronutrients intakes. Biochemical parameters were obtained from patient files. The incidence of gout was higher in men comparing to women. Individuals in the GOUT group consumed more alcohol and higher serum levels of vitamin B 12 , C-reactive protein (CRP), triglyceride, and uric acid. Individuals in the GOUT group had higher intakes of energy, protein, carbohydrate, fat, fructose, vitamin C, and vitamin B 12 . Triglyceride, uric acid, CRP, vitamin B 12 , and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Dietary factors can pose a risk for health problems in addition to GOUT and ASH, such as cardiovascular disease, diabetes, and obesity.