Canine histiocytic syndrome manifested as ulcerative gastroenterocolitis, skin lesions and lymphadenopathy - a case report

Histiocytic syndrome was diagnosed in a 7-year-old boxer bitch using histological and immunohistochemical methods. Necropsy confirmed the presence of enlarged superficial lymph nodes, two large ulcerated oval cutaneous masses one on the left lateral thoracic wall and one near to the vulva. In the ga...

Full description

Saved in:
Bibliographic Details
Published inVeterinární medicína Vol. 49; no. 8; pp. 312 - 316
Main Authors Revajova, V., Levkut, M., Kozak, M., Bilek, J., Magic, D., Herich, R.
Format Journal Article
LanguageEnglish
Published Prague Czech Academy of Agricultural Sciences (CAAS) 01.08.2004
Czech Academy of Agricultural Sciences
Subjects
Case reports
dog
Enlargement
Gastroenteritis
Gastrointestinal system
Gastrointestinal tract
histiocytic disorder
Intestine
Lymph nodes
Lymphadenopathy
Lymphoid tissue
Lysozyme
Macrophages
Necropsy
Nodules
Phagocytes
Polysaccharides
Saccharides
skin
Skin diseases
Skin lesions
Small intestine
Thorax
Ulcers
Vacuoles
Vulva
Online AccessGet full text

Cover

More Information
Summary:Histiocytic syndrome was diagnosed in a 7-year-old boxer bitch using histological and immunohistochemical methods. Necropsy confirmed the presence of enlarged superficial lymph nodes, two large ulcerated oval cutaneous masses one on the left lateral thoracic wall and one near to the vulva. In the gastrointestinal tract there were multiple ulcers apparently overlying nodules located in the submucosa of stomach, ulcers in the ileocaecal valve, and enlargement of lymphoid nodules in the small intestine manifested ulcerative gastroenteritis. Histologically, the thoracic wall mass showed infiltration of the tissue by macrophages with cytoplasmic vacuoles. The vacuoles contained PAS-positive polysaccharides. The macrophages were positive for alpha-1-antitrypsin and lysozyme by immunostaining. Lysozyme is a marker for phagocytic macrophages/histiocytes and may be used to confirm cells of this lineage in cases when there is any doubt.
ISSN:0375-8427
1805-9392
DOI:10.17221/5710-VETMED