Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen

• Published in: Biotechnology letters Vol. 23; no. 13; pp. 1051 - 1056
• Main Authors: DE LEON, A, BARBA-DE LA ROSA, A. P, MAYANI, H, GALINDO, E, RAMIREZ, O. T
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.01.2001; Springer Nature B.V
• Subjects: Bacteria; Biological and medical sciences; Biotechnology; Control algorithms; E coli; Escherichia coli; Fundamental and applied biological sciences. Psychology; Methods. Procedures. Technologies; Microbiology; Others; Various methods and equipments; Human; Cell culture; Escherichia coli; Control system; Hematopoietic cell; Algorithm; Adaptive control; Bioreactor; Animal; Microorganism culture; Bacteria; Dissolved oxygen; Differential integral proportional control; Enterobacteriaceae
• ISSN: 0141-5492; 1573-6776
• DOI: 10.1023/A:1010598121587

Two new dimensionless parameters (Φ and Ω) are proposed for calculating the proportional, integral, and derivative constants of a dissolved oxygen proportional integral-derivative (PID) feed-back control algorithm from knowledge of the growth rate, bioreactor design and operation variables. The values of Φ and Ω were determined for a broad range of Reynolds numbers (between 1000 to 40 000) during the exponential growth phase of two highly different processes: fermentations of recombinant Escherichia coli and cultures of human hematopoietic cells. The utility of Φ and Ω for use in dissolved oxygen self-tunning adaptive control algorithms is discussed.[PUBLICATION ABSTRACT]