Serum calcitonin gene-related peptide levels in women with polycystic ovary syndrome

• Published in: Archives of gynecology and obstetrics Vol. 287; no. 6; pp. 1235 - 1239
• Main Authors: Fenkci, Semin Melahat, Fenkci, Veysel, Oztekin, Ozer, Rota, Simin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2013; Springer Nature B.V
• Subjects: Adolescent; Adult; Androgens - blood; Blood Glucose - analysis; Calcitonin Gene-Related Peptide - blood; Cholesterol, HDL - blood; Endocrinology; Fasting; Female; Gynecology; Human Genetics; Humans; Hyperandrogenism - blood; Hyperandrogenism - complications; Hyperlipidemias - blood; Hyperlipidemias - complications; Insulin - blood; Insulin Resistance; Lipids - blood; Medicine; Medicine & Public Health; Metabolic disorders; Obesity, Abdominal - blood; Obesity, Abdominal - complications; Obstetrics/Perinatology/Midwifery; Peptides; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - complications; Postprandial Period; Reproductive Medicine; Waist Circumference; Insulin resistance; PCOS; CGRP; Dyslipidemia
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-012-2689-4

Purpose Calcitonin gene-related peptide (CGRP) is an amino acid neuropeptide with widespread expression. It has potent effects on lipid and energy metabolism. It induces insulin resistance. This study was planned to determine CGRP levels in women with polycystic ovary syndrome (PCOS). Methods Forty-seven women with PCOS and 34 healthy controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, postprandial and fasting glucose, insulin and other hormones (gonadotropins, androgens) and CGRP levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Results Waist measurements, postprandial and fasting glucose and fasting insulin levels and free androgen index and HOMA-IR were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower high-density lipoprotein cholesterol levels than healthy subjects. Serum CGRP levels were higher in study subjects than in controls, although it was statistically insignificant. Conclusions Serum CGRP level was not related with insulin resistance, ovarian hyperandrogenism and dyslipidemia in abdominally obese women with PCOS. These outcomes propose that CGRP may not play a pivotal role in the pathogenesis of PCOS.