Analysis of N6-methyladenosine-modified mRNAs in diabetic cataract

The prevalence of diabetes mellitus is increasing in resource limited settings. Simultaneously, there has been an increase in the number of novel therapies for the management of diabetes mellitus. However, use of novel antidiabetic therapies is limited because of major market access challenges in re...

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Published inWorld journal of diabetes Vol. 14; no. 7; pp. 1077 - 1090
Main Authors Cai, Lei, Han, Xiao-Yan, Li, Dan, Ma, Dong-Mei, Shi, Yu-Meng, Lu, Yi, Yang, Jin
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 15.07.2023
Subjects
Basic Study
Ferroptosis
N6-methyladenosine
Diabetic cataract
Epitranscriptomic microarray
RNA
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Summary:The prevalence of diabetes mellitus is increasing in resource limited settings. Simultaneously, there has been an increase in the number of novel therapies for the management of diabetes mellitus. However, use of novel antidiabetic therapies is limited because of major market access challenges in resource limited settings. Niching products to those patients with the highest absolute risk for major adverse cardiovascular outcomes, and thus most likely to benefit from the therapy, are less likely to have negative budget impact for funders. To improve access, and reduce morbidity and mortality, requires alignment amongst key stakeholders including patient advocacy groups, health care professional councils, national departments of health, the pharmaceutical industry, treasury and finance departments.
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Supported by the National Natural Science Foundation of China, No. 82171039.
Author contributions: Cai L and Han XY contributed equally to this work; Lu Y and Yang J contributed equally to this work; Cai L performed the experiments, analyzed the data, and wrote the original draft; Han XY collected the samples, performed the experiments, and also wrote the original draft; Li D designed the experiments; Ma DM and Shi YM performed the experiments; Lu Y and Yang J designed the experiments and revised the draft; and all authors read and approved the final manuscript.
Corresponding author: Jin Yang, MD, Chief Physician, Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China. jin_er76@hotmail.com
ISSN:1948-9358
1948-9358
DOI:10.4239/wjd.v14.i7.1077