Identification and Characterization of Chemical Constituents from Ammopiptanthus nanus Stem and Their Metabolites in Rats by UHPLC-Q-TOF-MS/MS

as a Kirgiz medicine is widely used for the treatment of frostbite and chronic rheumatoid arthritis. However, due to a lack of systematic research on the chemical components of and their metabolites, the bioactive components in it remain unclear. Herein, a reliable strategy based on UHPLC-Q-TOF-MS/M...

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Published inPlanta medica Vol. 90; no. 2; p. 138
Main Authors Chen, Guanru, Sun, Yanpei, Yushan, Dilnur, Shaerbayi, Nuerjiamali, Zhang, Hongjuan, He, Hongliang, Jin, Yang, Chen, Lina
Format Journal Article
LanguageEnglish
Published Germany 01.02.2024
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Summary:as a Kirgiz medicine is widely used for the treatment of frostbite and chronic rheumatoid arthritis. However, due to a lack of systematic research on the chemical components of and their metabolites, the bioactive components in it remain unclear. Herein, a reliable strategy based on UHPLC-Q-TOF-MS/MS was established to comprehensively analyze the chemical components and their metabolites . In total, 59 compounds were identified from stem extract, among which 14 isoflavones, 10 isoprenylated isoflavones, 4 polyhydroxy flavonoids, 9 alkaloids and 1 polyol were characterized for the first time. After oral administration of stem extract, 30 prototype constituents and 28 metabolites (12 phase I and 16 phase II metabolites) were speculated on and identified in rat serum, urine and feces. Furthermore, the metabolic pathways of the chemical components were systematically analyzed and proposed. In conclusion, the chemical components from stem and their metabolites were first studied, which may provide useful chemical information for further study on the effective material basis and pharmacological mechanism of .
ISSN:1439-0221
DOI:10.1055/a-2184-1134