Antimicrobial and Efflux Inhibitor Activity of Usnic Acid Against Mycobacterium abscessus

New drugs are needed to treat infections with antimicrobial-resistant ; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against . Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evalu...

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Bibliographic Details
Published inPlanta medica Vol. 84; no. 17; p. 1265
Main Authors Ramis, Ivy B, Vianna, Júlia S, Reis, Ana Júlia, von Groll, Andrea, Ramos, Daniela F, Viveiros, Miguel, da Silva, Pedro E Almeida
Format Journal Article
LanguageEnglish
Published Germany 01.11.2018
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Benzofurans - pharmacology
Drug Interactions
Ethidium - metabolism
Microbial Sensitivity Tests
Mycobacterium abscessus - drug effects
Mycobacterium abscessus - metabolism
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Summary:New drugs are needed to treat infections with antimicrobial-resistant ; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against . Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine. In conclusion, usnic acid showed both antimicrobial and EI activity, indicating that this natural compound may be a promising scaffold for new drugs against this difficult-to-treat microorganism.
ISSN:1439-0221
DOI:10.1055/a-0639-5412