Association of a MYCL1 single nucleotide polymorphism, rs3134613, with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer in a southeast Chinese population

• Published in: DNA and cell biology Vol. 29; no. 12; p. 739
• Main Authors: Chen, Shu-Qin, Lin, Xian-Dong, Zhu, Jin-Wei, Tang, Yang, Lin, Jian-Yin
• Format: Journal Article
• Language: English
• Published: United States 01.12.2010
• Subjects: Alleles; Asian Continental Ancestry Group - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-myc - genetics; Stomach Neoplasms - genetics
• ISSN: 1557-7430
• DOI: 10.1089/dna.2010.1096

A MYCL1 single nucleotide polymorphism, rs3134613, has been reported to play an important role in many cancers. However, its involvement in gastric cancer is controversial. The aim of the study was to investigate the influence of rs3134613 on the development and progression of gastric cancer in a southeast Chinese population. Genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism in 317 gastric cancer patients and 200 cancer-free controls. Data show that the risk of diffuse-type gastric cancer in carriers with the T allele (T/T or G/T genotype) was higher than that in carriers with the G/G genotype (adjusted odds ratio [OR] = 2.601, 95% confidence interval [CI] = 1.431-4.895, p = 0.003). The risk of diffuse-type gastric cancer in T allele carriers was higher than that in G allele carriers (adjusted OR = 1.594, 95% CI = 1.157-2.286, p = 0.009). The risk of poorly differentiated cancer in carriers with the T allele (T/T or G/T genotype) was higher than that in carriers with the G/G genotype (adjusted OR = 1.963, 95% CI = 1.156-3.325, p = 0.015). The results demonstrate that rs3134613 is associated with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer. rs3134613 may be used as a potential marker to identify individuals who are at high risk of diffuse-type gastric cancer.