Raman detection of cell proliferation probes with antiresonance-guiding hollow fibers

Antiresonance-guiding hollow-core fibers are shown to enable highly sensitive detection of cell proliferation probes using Raman scattering within the region where the cellular Raman activity is minimal. We demonstrate that such fibers can substantially reduce the level of the background compared to...

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Bibliographic Details
Published inOptics letters Vol. 37; no. 22; p. 4642
Main Authors Doronina-Amitonova, Lyubov V, Fedotov, Il'ya V, Fedotov, Andrei B, Anokhin, Konstantin V, Hu, Ming-lie, Wang, Ching-yue, Zheltikov, Aleksei M
Format Journal Article
LanguageEnglish
Published United States 15.11.2012
Subjects
Cell Proliferation
Cell Survival
Optical Fibers
Optical Phenomena
Spectrum Analysis, Raman - instrumentation
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Summary:Antiresonance-guiding hollow-core fibers are shown to enable highly sensitive detection of cell proliferation probes using Raman scattering within the region where the cellular Raman activity is minimal. We demonstrate that such fibers can substantially reduce the level of the background compared to standard index-guiding optical fibers, thus radically improving the sensitivity of Raman detection of DNA synthesis in cells and offering a powerful tool for fiber-based live-cell imaging.
ISSN:1539-4794
DOI:10.1364/OL.37.004642