Synthesis of new transition metal complexes of 1H-perimidine derivatives having antimicrobial and anti-inflammatory activities
New series of 1 H -perimidine-2-thiol derivatives and (2-substituted-1 H -perimidin-1-yl)ethane-1,2-dione derivatives and their ligands (C 24 H 14 N 4 S 2 O 2 ) H 2 L 1 and (C 26 H 18 N 4 S 2 O 2 ) H 2 L 2 have been synthesized with transition metal ions, e.g., Copper (II), Silver (I), Cobalt (II) a...
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Published in | Research on chemical intermediates Vol. 38; no. 7; pp. 1527 - 1550 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Springer Netherlands
01.09.2012
|
Subjects | |
Online Access | Get full text |
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Summary: | New series of 1
H
-perimidine-2-thiol derivatives and (2-substituted-1
H
-perimidin-1-yl)ethane-1,2-dione derivatives and their ligands (C
24
H
14
N
4
S
2
O
2
) H
2
L
1
and (C
26
H
18
N
4
S
2
O
2
) H
2
L
2
have been synthesized with transition metal ions, e.g., Copper (II), Silver (I), Cobalt (II) and Ruthenium (III) were prepared and evaluated for their antimicrobial, analgesic and anti-inflammatory activities. The synthesized compounds and their complexes were characterized by elemental analysis,
1
H NMR, IR, MS, molar conductance, thermal gravimetric analysis and electronic spectra. All results revealed that compounds
3
and
13
exhibited high inhibitory effects against some bacterial strains by the disc diffusion method. On the other hand, compounds
2
,
3
,
7
and
12
displayed potent anti-inflammatory activity. |
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ISSN: | 0922-6168 1568-5675 1568-5675 |
DOI: | 10.1007/s11164-011-0482-9 |