Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments

Severe digoxin toxicosis in a 13-year-old mixed-breed dog with dilated cardiomyopathy was successfully treated with i.v. administration of ovine digoxin-specific IgG Fab fragments. Management of this dog following treatment with Fab fragments was complicated by hypomagnesemia and loss of the positiv...

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Bibliographic Details
Published inJournal of the American Veterinary Medical Association Vol. 215; no. 12; p. 1808
Main Authors Ward, D M, Forrester, S D, DeFrancesco, T C, Troy, G C
Format Journal Article
LanguageEnglish
Published United States 15.12.1999
Subjects
Animals
Anti-Arrhythmia Agents - adverse effects
Anti-Arrhythmia Agents - immunology
Anti-Arrhythmia Agents - therapeutic use
Antihypertensive Agents - therapeutic use
Blood Cell Count - veterinary
Blood Chemical Analysis - veterinary
Cardiomyopathy, Dilated - drug therapy
Cardiomyopathy, Dilated - veterinary
Cardiotonic Agents - therapeutic use
Digoxin - adverse effects
Digoxin - immunology
Digoxin - therapeutic use
Dog Diseases - chemically induced
Dog Diseases - drug therapy
Dog Diseases - physiopathology
Dogs
Electrocardiography - veterinary
Enalapril - therapeutic use
Female
Immunoglobulin Fab Fragments - administration & dosage
Immunoglobulin Fab Fragments - therapeutic use
Isoproterenol - therapeutic use
Magnesium Deficiency - veterinary
Magnesium Sulfate - therapeutic use
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Summary:Severe digoxin toxicosis in a 13-year-old mixed-breed dog with dilated cardiomyopathy was successfully treated with i.v. administration of ovine digoxin-specific IgG Fab fragments. Management of this dog following treatment with Fab fragments was complicated by hypomagnesemia and loss of the positive inotropic effect of digoxin.
ISSN:0003-1488
DOI:10.2460/javma.1999.215.12.1808