A multiple-parameter comparison of immunocompetence and tumor resistance in aged BALB/c mice
Several parameters of cell-mediated and humoral immunity were measured in young-adult and aged BALB/c mice and compared with resistance to the ascites from of intraperitoneal induced P815 mastocytoma. It was found that the age-related decline of in vitro phytohemagglutinin (PHA) responsiveness by sp...
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Published in | Mechanisms of ageing and development Vol. 6; no. 1; pp. 15 - 24 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
1977
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Subjects | |
Online Access | Get full text |
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Summary: | Several parameters of cell-mediated and humoral immunity were measured in young-adult and aged BALB/c mice and compared with resistance to the ascites from of intraperitoneal induced P815 mastocytoma. It was found that the age-related decline of
in vitro phytohemagglutinin (PHA) responsiveness by spleen cells approximated the marked decrease of old mice to tumor-cell challenge and approached that characteristically seen in humoral immunity. Thus, decreased PHA responsiveness of splenic lymphocytes provided as sensitive an estimate of the age-related decline of immunocompetence in old mice as other classical parameters of cell-mediated immunity (
e.g.-graft-
versus-host reaction or
in vivo cellular proliferation of parental spleen cells in lethally-irradiated F
1 recipients). Results could be interpreted to represent a decreased ability of noncycling T-cells to be released to a functional cycling state. |
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ISSN: | 0047-6374 1872-6216 |
DOI: | 10.1016/0047-6374(77)90003-3 |