A multiple-parameter comparison of immunocompetence and tumor resistance in aged BALB/c mice

Several parameters of cell-mediated and humoral immunity were measured in young-adult and aged BALB/c mice and compared with resistance to the ascites from of intraperitoneal induced P815 mastocytoma. It was found that the age-related decline of in vitro phytohemagglutinin (PHA) responsiveness by sp...

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Bibliographic Details
Published inMechanisms of ageing and development Vol. 6; no. 1; pp. 15 - 24
Main Authors Perkins, Eugene H., Cacheiro, Lucia H.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 1977
Subjects
Aging
Animals
Antibody Formation
Cell Division
Female
Graft vs Host Reaction
Hemolytic Plaque Technique
Immunity, Cellular
In Vitro Techniques
Lectins
Lymph Nodes - immunology
Male
Mast-Cell Sarcoma - immunology
Mice
Mice, Inbred BALB C
Sarcoma, Experimental - immunology
Spleen - immunology
T-Lymphocytes - immunology
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Summary:Several parameters of cell-mediated and humoral immunity were measured in young-adult and aged BALB/c mice and compared with resistance to the ascites from of intraperitoneal induced P815 mastocytoma. It was found that the age-related decline of in vitro phytohemagglutinin (PHA) responsiveness by spleen cells approximated the marked decrease of old mice to tumor-cell challenge and approached that characteristically seen in humoral immunity. Thus, decreased PHA responsiveness of splenic lymphocytes provided as sensitive an estimate of the age-related decline of immunocompetence in old mice as other classical parameters of cell-mediated immunity ( e.g.-graft- versus-host reaction or in vivo cellular proliferation of parental spleen cells in lethally-irradiated F 1 recipients). Results could be interpreted to represent a decreased ability of noncycling T-cells to be released to a functional cycling state.
ISSN:0047-6374
1872-6216
DOI:10.1016/0047-6374(77)90003-3